Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: SLC30A8 knockout K562 cell lysate; Predicted MW: 40,35kDa Observed MW: 35kDa Primary Ab: 3ug/ml Rabbit Anti-Human SLC30A8 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Solute Carrier Family 30 Member 8 (SLC30A8) Polyclonal Antibody | anti-SLC30A8 antibody
Cy3-Linked Polyclonal Antibody to Solute Carrier Family 30 Member 8 (SLC30A8)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: SLC30A8 knockout K562 cell lysate; Predicted MW: 40,35kDa Observed MW: 35kDa Primary Ab: 3ug/ml Rabbit Anti-Human SLC30A8 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: SLC30A8 knockout K562 cell lysate; Predicted MW: 40,35kDa Observed MW: 35kDa Primary Ab: 3ug/ml Rabbit Anti-Human SLC30A8 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Uniprot Description
SLC30A8: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Vesicle
Chromosomal Location of Human Ortholog: 8q24.11
Cellular Component: cytoplasmic vesicle; Golgi apparatus; plasma membrane; secretory granule; secretory granule membrane
Molecular Function: protein binding; protein homodimerization activity; zinc ion binding; zinc ion transmembrane transporter activity
Biological Process: cellular zinc ion homeostasis; glucose homeostasis; insulin secretion; positive regulation of insulin secretion; response to glucose stimulus; response to zinc ion; sequestering of zinc ion; zinc ion transport
Disease: Diabetes Mellitus, Noninsulin-dependent
Research Articles on SLC30A8
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Product Notes
The SLC30A8 slc30a8 (Catalog #AAA2074524) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cy3-Linked Polyclonal Antibody to Solute Carrier Family 30 Member 8 (SLC30A8) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Solute Carrier Family 30 Member 8 (SLC30A8) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the SLC30A8 slc30a8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Solute Carrier Family 30 Member 8 (SLC30A8), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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