Rabbit anti-Human, Rat SOCS7 Polyclonal Antibody | anti-SOCS7 antibody

SOCS7 Antibody

Cat. Num. AAA7052417

• Gene Names: SOCS7; NAP4; NCKAP4
• Reactivity: Human, Rat
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: SOCS7; Polyclonal Antibody; SOCS7 Antibody; Suppressor of cytokine signaling 7; SOCS-7; Nck; Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4; NAP4; SOCS6; anti-SOCS7 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 581

• Applicable Applications for anti-SOCS7 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:5000; IF: 1:50-1:200
• Immunogen: Recombinant Human Suppressor of cytokine signaling 7 protein (6-165AA)
• Conjugation: Non-conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in: MCF-7 whole cell lysate,Hela whole cell lysate,Jurkat whole cell lysate,U87 whole cell lysate,Rat heart tissue,Rat liver tissueAll lanes: SOCS7 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 63,38 KDaObserved band size: 63 KDa)

Immunofluorescence (IF)

(Immunofluorescent analysis of HepG2 cells using MBS7052417 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-SOCS7 antibody

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 53831997
• NCBI GeneID: 30837
• NCBI Accession #: NP_055413.1
• NCBI GenBank Nucleotide #: NM_014598.3
• UniProt Accession #: O14512; Q0IJ63; A2VCU2
• Molecular Weight: 37,461 Da
• NCBI Official Full Name: suppressor of cytokine signaling 7
• NCBI Official Synonym Full Names: suppressor of cytokine signaling 7
• NCBI Official Symbol: SOCS7
• NCBI Official Synonym Symbols: NAP4; NCKAP4
• NCBI Protein Information: suppressor of cytokine signaling 7
• UniProt Protein Name: Suppressor of cytokine signaling 7
• Protein Family: Suppressor of cytokine signaling
• UniProt Gene Name: SOCS7
• UniProt Synonym Gene Names: NAP4; SOCS6; SOCS-7; NAP-4

Uniprot Description

SOCS7: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytoplasm

Molecular Function: protein binding; protein kinase inhibitor activity

Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity