Rabbit anti-Human SOCS6 Polyclonal Antibody | anti-SOCS6 antibody

SOCS6, NT (SOCS6, CIS4, SOCS4, Suppressor of cytokine signaling 6, Cytokine-inducible SH2 protein 4, Suppressor of cytokine signaling 4) (APC)

Cat. Num. AAA6349761

• Gene Names: SOCS6; CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SOCS6; Polyclonal Antibody; NT (SOCS6; CIS4; SOCS4; Suppressor of cytokine signaling 6; Cytokine-inducible SH2 protein 4; Suppressor of cytokine signaling 4) (APC); Suppressor of cytokine signaling 4; anti-SOCS6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-SOCS6 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: SOCS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-69 amino acids from the N-terminal region of human SOCS6.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SOCS6 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SOCS6 antibody detected the SOCS6 protein (arrow).)

Immunohistochemistry (IHC)

(SOCS6 Antibody (N-term) (AP14118a)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SOCS6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-SOCS6 antibody

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.

Product Categories/Family for anti-SOCS6 antibody

Antibodies; SOCS

References

Bailey, S.D., et al. Diabetes Care (2010). In press: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Choi, Y.B., et al. J. Biol. Chem. 285(10):7271-7280(2010). Lai, R.H., et al. Gene 448(1):64-73(2009). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 21450785
• NCBI GeneID: 9306
• NCBI Accession #: NP_004223.2
• NCBI GenBank Nucleotide #: NM_004232.4
• UniProt Accession #: O14544; Q8WUM3
• Molecular Weight: 59,528 Da
• NCBI Official Full Name: suppressor of cytokine signaling 6
• NCBI Official Synonym Full Names: suppressor of cytokine signaling 6
• NCBI Official Symbol: SOCS6
• NCBI Official Synonym Symbols: CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060
• NCBI Protein Information: suppressor of cytokine signaling 6
• UniProt Protein Name: Suppressor of cytokine signaling 6
• Protein Family: Suppressor of cytokine signaling
• UniProt Gene Name: SOCS6
• UniProt Synonym Gene Names: CIS4; SOCS4; SOCS-6; CIS-4; SOCS-4

NCBI Description

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

Uniprot Description

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.