Western Blot (WB)
(Western Blot analysis of SOCS4 expression in transfected 293T cell line by SOCS4 polyclonal antibody. Lane 1: SOCS4 transfected lysate (50.6kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human SOCS4 Polyclonal Antibody | anti-SOCS4 antibody
SOCS4 (Suppressor of Cytokine Signaling 4, SOCS-4, Suppressor of Cytokine Signaling 7, SOCS7, SOCS-7) (PE)
Western Blot (WB)
(Western Blot analysis of SOCS4 expression in transfected 293T cell line by SOCS4 polyclonal antibody. Lane 1: SOCS4 transfected lysate (50.6kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of SOCS4 expression in transfected 293T cell line by SOCS4 polyclonal antibody. Lane 1: SOCS4 transfected lysate (50.6kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
SOCS4: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 14q22.1
Cellular Component: cytoplasm
Molecular Function: protein binding; protein kinase inhibitor activity
Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of JAK-STAT cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of growth
Research Articles on SOCS4
Similar Products
Product Notes
The SOCS4 socs4 (Catalog #AAA6394750) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SOCS4 (Suppressor of Cytokine Signaling 4, SOCS-4, Suppressor of Cytokine Signaling 7, SOCS7, SOCS-7) (PE) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SOCS4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SOCS4 socs4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOCS4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
