Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded H. kideny section using SNX3 Antibody (Center). MBS9210652 was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.)
Rabbit SNX3 Polyclonal Antibody | anti-SNX3 antibody
SNX3 Antibody (Center)
WB~~1:1000
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded H. kideny section using SNX3 Antibody (Center). MBS9210652 was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded H. kideny section using SNX3 Antibody (Center). MBS9210652 was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.)
Western Blot (WB)
(Western blot analysis of lysates from A431, THP-1 cell line and mouse spleen tissue lysate (from left to right), using SNX3 Antibody (Center). MBS9210652 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.)
Western Blot (WB)
(Western blot analysis of lysates from A431, THP-1 cell line and mouse spleen tissue lysate (from left to right), using SNX3 Antibody (Center). MBS9210652 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.)
Western Blot (WB)
(Western blot analysis of lysate from A2058 cell line, using SNX3 Antibody (Center). MBS9210652 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)
Western Blot (WB)
(Western blot analysis of lysate from A2058 cell line, using SNX3 Antibody (Center). MBS9210652 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)
Western Blot (WB)
(SNX3 Antibody (Center) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the SNX3 antibody detected the SNX3 protein (arrow).)
Western Blot (WB)
(SNX3 Antibody (Center) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the SNX3 antibody detected the SNX3 protein (arrow).)
Members of this family contain a phox (PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular
trafficking. This protein does not contain a coiled coil region,
like most family members. This protein interacts with
phosphatidylinositol-3-phosphate, and is involved in protein
trafficking.
Pons, V., et al. PLoS Biol. 6 (9), E214 (2008) :
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Dong, H., et al. Acta Biochim. Biophys. Sin. (Shanghai) 39(7):540-546(2007)
Kumar, R.A., et al. BMC Med. Genet. 8, 48 (2007) :
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Uniprot Description
SNX3: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. A chromosomal aberration involving SNX3 may be a cause of microphthalmia syndromic type 8 (MCOPS8). Translocation t(6;13)(q21;q12). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS8 is a very rare congenital syndrome characterized by microcephaly, microphthalmia, ectrodactyly of the lower limbs and prognathism. Intellectual deficit has been reported. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: extrinsic to membrane; intracellular membrane-bound organelle; clathrin-coated vesicle; retromer complex; early endosome membrane; early endosome; cytoplasm; endosome membrane; cytosol
Molecular Function: protein binding; phosphatidylinositol-5-phosphate binding; protein phosphatase binding; phosphatidylinositol 3-phosphate binding
Biological Process: hemoglobin biosynthetic process; negative regulation of phagocytosis; negative regulation of virion penetration into host cell; vesicle organization and biogenesis; regulation of Wnt receptor signaling pathway; transferrin transport; protein to membrane docking; regulation of cellular protein metabolic process; regulation of intracellular protein transport; response to bacterium; membrane invagination; negative regulation of protein transport; negative regulation of protein catabolic process
Disease: Microphthalmia, Syndromic 8
Research Articles on SNX3
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Product Notes
The SNX3 snx3 (Catalog #AAA9210652) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 78-105. The SNX3 Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's SNX3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). IHC~~1:25 WB~~1:1000. Researchers should empirically determine the suitability of the SNX3 snx3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNX3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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