Rabbit SNX27 Polyclonal Antibody | anti-SNX27 antibody

SNX27 Polyclonal Antibody

Cat. Num. AAA2525176

• Gene Names: SNX27; MRT1; MY014
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: SNX27; Polyclonal Antibody; SNX27 Polyclonal Antibody; MRT1; MY014; anti-SNX27 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.2mg/mL (varies by lot)
• Sequence Length: 528

• Applicable Applications for anti-SNX27 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Recombinant protein of human SNX27
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using SNX27 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-SNX27 antibody

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.

NCBI and Uniprot Product Information

• NCBI GI #: 31742501
• NCBI GeneID: 81609
• NCBI Accession #: NP_112180.4
• NCBI GenBank Nucleotide #: NM_030918.5
• Molecular Weight: 27,781 Da
• NCBI Official Full Name: sorting nexin-27
• NCBI Official Synonym Full Names: sorting nexin family member 27
• NCBI Official Symbol: SNX27
• NCBI Official Synonym Symbols: MRT1; MY014
• NCBI Protein Information: sorting nexin-27; methamphetamine-responsive transcript 1
• UniProt Protein Name: Sorting nexin-27
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX27
• UniProt Synonym Gene Names: KIAA0488
• UniProt Entry Name: SNX27_HUMAN

NCBI Description

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]

Uniprot Description

SNX27: Involved in endocytic trafficking. In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: nucleoplasm; early endosome membrane; retromer complex; early endosome; cytoplasm; immunological synapse; cytosol

Molecular Function: protein binding; phosphatidylinositol 3-phosphate binding

Biological Process: intracellular protein transport; establishment of natural killer cell polarity; endosome to lysosome transport; signal transduction; endosome transport