Rabbit anti-Human SNX21 Polyclonal Antibody | anti-SNX21 antibody

Anti-SNX21 Antibody, Rabbit Polyclonal

Cat. Num. AAA8109769

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: SNX21; Polyclonal Antibody; Anti-SNX21 Antibody; Rabbit Polyclonal; SNX21 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-dJ337O18.4 Antibody; Anti-PP3993 Antibody; Anti-RP3-337O18.7 Antibody; Anti-SNX-L Antibody; anti-SNX21 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human SNX21
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-SNX21 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:50-1:200
• Immunogen: E Coli-derived Human SNX21 fragment
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with E Coli-derived Human SNX21 fragment, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human SNX21 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining of human SNX21 in human lymph node with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-SNX21 antibody

Sorting nexins (SNX) orchestrate membrane trafficking and signaling events required for the proper distribution of proteins within the endosomal network. Their phox homology (PX) domain acts as a phosphoinositide (PI) recognition module that targets them to specific endocytic membrane domains. Comprising over 30 proteins in humans, SNXs are classified into sub-groups based on the presence of additional functional domains. One SNX sub-group that in humans comprises sorting nexin-20 (SNX20) and sorting nexin-21 (SNX21) are the SNX-PXB proteins. These proteins possess a C-terminal PX-associated B (PXB) domain which displays a tetratricopeptide repeat (TPR) fold that is typically involved in protein-protein interactions. While SNX20 and SNX21 share the same overall domain organisation and approximately 40% sequence conservation at the amino acid level, they are distinguished by an N-terminal extension in SNX21 that is predicted to include a short alpha-helical structure. SNX-L (or SNX21) gene includes 4 exons and 3 introns, and is located on chromosome 20q12-13.1 region, encompassing 8 kb. The SNX-L protein has a common PX domain shared by all SNX family members. The similarity of SNX-L PX domain to the PX consensus sequence is over 40%. PX domains have been shown to associate with specific phospholipids and membrane compartments.

References

Danson CM, et al. (2018) Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin. J Cell Sci 131 (17): jcs211672.Danson C, et al. (2013) Snx15 links clathrin endocytosis to the ptdins3p early endosome independently of the appl1 endosome. J Cell Sci 126 (Pt 21): 4885-4899.Clairfeuille T, et al. (2015) Structure and membrane binding properties of the endosomal tetratricopeptide repeat (tpr) domain-containing sorting nexins snx20 and snx21. J Biol Chem 290 (23): 14504-14517.