Rabbit SNX10 Polyclonal Antibody | anti-SNX10 antibody

SNX10 Polyclonal Antibody

Cat. Num. AAA3015260

• Gene Names: SNX10; OPTB8
• Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: SNX10; Polyclonal Antibody; SNX10 Polyclonal Antibody; 2410004M09Rik; MGC109202; MGC33054; SNX10_HUMAN; Sorting nexin 10; Sorting nexin-10. ; anti-SNX10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
• Clonality: Polyclonal
• Specificity: SNX10 Polyclonal Antibody detects endogenous levels of SNX10 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-SNX10 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from human SNX10:11-100/201
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Primary: Anti-SNX10 at 1/1000 dilution)

Related Product Information for anti-SNX10 antibody

Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. SNXs are widely expressed, although the tissue distribution of each SNX mRNA varies. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNX10 (Sorting nexin-10) is a 201 amino acid protein that contains one phox domain and belongs to the SNX family. Like other members of the SNX family, SNX10 is thought to play a role in intracellular trafficking events throughout the cell.

NCBI and Uniprot Product Information

• NCBI GI #: 315360662
• NCBI GeneID: 29887
• NCBI Accession #: NP_001186766.1
• NCBI GenBank Nucleotide #: NM_001199837.1
• UniProt Accession #: Q9Y5X0; Q8IYT5; E9PFH5
• Molecular Weight: 23,598 Da
• NCBI Official Full Name: sorting nexin-10 isoform 2
• NCBI Official Synonym Full Names: sorting nexin 10
• NCBI Official Symbol: SNX10
• NCBI Official Synonym Symbols: OPTB8
• NCBI Protein Information: sorting nexin-10
• UniProt Protein Name: Sorting nexin-10
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX10
• UniProt Entry Name: SNX10_HUMAN

NCBI Description

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Uniprot Description

SNX10: May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis. Overexpression causes formation of huge vacuoles. Belongs to the sorting nexin family.

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: centrosome; endoplasmic reticulum; nucleus

Molecular Function: ATPase binding; phosphatidylinositol binding

Biological Process: protein transport; endosome organization and biogenesis; vesicle organization and biogenesis; cilium biogenesis; endocytosis; osteoclast differentiation

Disease: Osteopetrosis, Autosomal Recessive 8