Rabbit anti-Human Snurportin 1 Polyclonal Antibody | anti-SPN1 antibody

Snurportin 1 (Snurportin-1, SNUPN, SPN1, KPNBL, RNA U Transporter 1, RNUT1) (PE)

Cat. Num. AAA6394651

• Gene Names: SNUPN; KPNBL; RNUT1; Snurportin1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Snurportin 1; Polyclonal Antibody; Snurportin 1 (Snurportin-1; SNUPN; SPN1; KPNBL; RNA U Transporter 1; RNUT1) (PE); anti-SPN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SNUPN.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 1420

• Applicable Applications for anti-SPN1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human SNUPN, aa1-360 (NP_005692.1).
• Immunogen Sequence: MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SNUPN rabbit polyclonal antibody. Western Blot analysis of SNUPN expression in human liver.)

Western Blot (WB)

(Western Blot analysis of SNUPN expression in transfected 293T cell line by SNUPN polyclonal antibody. Lane 1: SNUPN transfected lysate (41.1kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-SPN1 antibody

Antibodies; Transport Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 1653962468
• NCBI GeneID: 10073
• NCBI Accession #: NM_005701.4
• NCBI GenBank Nucleotide #: NM_005701
• UniProt Accession #: O95149
• NCBI Official Full Name: Homo sapiens snurportin 1 (SNUPN), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: snurportin 1
• NCBI Official Symbol: SNUPN
• NCBI Official Synonym Symbols: KPNBL; RNUT1; Snurportin1
• NCBI Protein Information: snurportin-1
• UniProt Protein Name: Snurportin-1
• Protein Family: Septin
• UniProt Gene Name: SNUPN
• UniProt Synonym Gene Names: RNUT1; SPN1
• UniProt Entry Name: SPN1_HUMAN

NCBI Description

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RNUT1: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family.

Protein type: Nuclear import; RNA-binding

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: nuclear pore; cytosol

Molecular Function: protein transporter activity; RNA cap binding

Biological Process: spliceosomal snRNP biogenesis; protein import into nucleus; gene expression