Western Blot (WB)
(Western Blot analysis of SNCB in Rat brain tissue, Human cerebrum tissue, Human cerebella tissue lysates in order using SNCB Rabbit pAb at dilution 1/450)
Rabbit SNCB Polyclonal Antibody | anti-SNCB antibody
SNCB Rabbit pAb
IHC-P: 1:30-1:150
Western Blot (WB)
(Western Blot analysis of SNCB in Rat brain tissue, Human cerebrum tissue, Human cerebella tissue lysates in order using SNCB Rabbit pAb at dilution 1/450)
Western Blot (WB)
(Western Blot analysis of SNCB in Rat brain tissue, Human cerebrum tissue, Human cerebella tissue lysates in order using SNCB Rabbit pAb at dilution 1/450)
Immunohistochemistry (IHC)
(Immunohistochemistry of SNCB in paraffin-embedded Human brain tissue using SNCB Rabbit pAb at dilution 1/45. Predicted cell location: Cytoplasm)
Immunohistochemistry (IHC)
(Immunohistochemistry of SNCB in paraffin-embedded Human brain tissue using SNCB Rabbit pAb at dilution 1/45. Predicted cell location: Cytoplasm)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
SNCB: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May play a role in neuronal plasticity, is abundant in neurofibrillary lesions of Alzheimer's patients. Highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: nucleoplasm; Golgi apparatus; growth cone; mitochondrion; cell soma; cytoplasm; terminal button; inclusion body
Molecular Function: phospholipase inhibitor activity; beta-tubulin binding; calcium ion binding; alpha-tubulin binding
Biological Process: synaptic transmission; negative regulation of catalytic activity; synapse organization and biogenesis; negative regulation of neuron apoptosis; dopamine metabolic process
Disease: Dementia, Lewy Body
Research Articles on SNCB
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Product Notes
The SNCB sncb (Catalog #AAA4760838) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SNCB Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SNCB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:500-1:2000 IHC-P: 1:30-1:150. Researchers should empirically determine the suitability of the SNCB sncb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNCB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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