Rabbit anti-Mouse, Rat SNAI1 Polyclonal Antibody | anti-SNAI1 antibody

SNAI1 Polyclonal Antibody

Cat. Num. AAA2556140

• Gene Names: Snai1; Sna; Sna1; Snail; Snail1
• Reactivity: Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: SNAI1; Polyclonal Antibody; SNAI1 Polyclonal Antibody; dJ710H13.1; Protein sna; Protein snail homolog 1; Protein snail homolog; SLUGH2; SNA; Sna protein; SNAH; SNAI; snai1; Snail 1 homolog; Snail 1 zinc finger protein; SNAIL; Snail family transcriptional repressor 1; Snail homolog 1 (Drosophila); Drosophila; homolog of; 1; SNAIL1; Zinc finger protein SNAI1; anti-SNAI1 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
• Concentration: 380 mug/mL (varies by lot)
• Sequence Length: 264

• Applicable Applications for anti-SNAI1 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:1600
• Immunogen: KLH conjugated synthetic peptide corresponding to Mouse Snai1
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded mouse testis using SNAI1 Polyclonal Antibody at dilution of 1:600.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded Rat testis using SNAI1 Polyclonal Antibody at dilution of 1:600.)

Related Product Information for anti-SNAI1 antibody

The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.

Product Categories/Family for anti-SNAI1 antibody

Cancer; Cardiovascular; Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 6755586
• NCBI GeneID: 20613
• NCBI Accession #: NP_035557.1
• NCBI GenBank Nucleotide #: NM_011427.3
• UniProt Accession #: Q02085
• Molecular Weight: 29,190 Da
• NCBI Official Full Name: zinc finger protein SNAI1
• NCBI Official Synonym Full Names: snail family zinc finger 1
• NCBI Official Symbol: Snai1
• NCBI Official Synonym Symbols: Sna; Sna1; Snail; Snail1
• NCBI Protein Information: zinc finger protein SNAI1
• UniProt Protein Name: Zinc finger protein SNAI1
• Protein Family: Protein snail
• UniProt Gene Name: Snai1
• UniProt Synonym Gene Names: Sna; Protein sna

Uniprot Description

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Associates with EGR1 and SP1 to mediate 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3'. In addition, may also activate the CDKN2B promoter by itself.