Western Blot (WB)
(Western BlotPositive WB detected in: Jurkat whole cell lysate,Mouse lung tissue,Mouse kidney tissueAll lanes: SMARCAL1 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 106 KDaObserved band size: 106 KDa)
Rabbit anti-Human, Mouse SMARCAL1 Polyclonal Antibody | anti-SMARCAL1 antibody
SMARCAL1 Antibody
IF: 1:50-1:200
Western Blot (WB)
(Western BlotPositive WB detected in: Jurkat whole cell lysate,Mouse lung tissue,Mouse kidney tissueAll lanes: SMARCAL1 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 106 KDaObserved band size: 106 KDa)
Western Blot (WB)
(Western BlotPositive WB detected in: Jurkat whole cell lysate,Mouse lung tissue,Mouse kidney tissueAll lanes: SMARCAL1 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 106 KDaObserved band size: 106 KDa)
Immunofluorescence (IF)
(Immunofluorescent analysis of Hela cells using MBS7053325 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunofluorescence (IF)
(Immunofluorescent analysis of Hela cells using MBS7053325 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. [provided by RefSeq, Jul 2008]
Uniprot Description
SMARCAL1: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. Defects in SMARCAL1 are a cause of Schimke immuno-osseous dysplasia (SIOD). SIOD causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema. Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: DNA replication factor A complex; nucleoplasm; nucleus
Molecular Function: DNA-dependent ATPase activity; protein binding
Biological Process: DNA metabolic process; regulation of transcription from RNA polymerase II promoter; replication fork processing; response to DNA damage stimulus
Disease: Immunoosseous Dysplasia, Schimke Type
Research Articles on SMARCAL1
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Product Notes
The SMARCAL1 smarcal1 (Catalog #AAA7053325) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SMARCAL1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SMARCAL1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF). WB: 1:500-1:5000 IF: 1:50-1:200. Researchers should empirically determine the suitability of the SMARCAL1 smarcal1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SMARCAL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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