Western Blot (WB)
(Western blot analysis of SLUG expression in MCF7 (A), mouse heart (B), rat heart (C), rat brain (D) whole cell lysates.)
Rabbit SLUG Polyclonal Antibody | anti-SNAI2 antibody
Anti-SLUG Antibody
Western Blot (WB)
(Western blot analysis of SLUG expression in MCF7 (A), mouse heart (B), rat heart (C), rat brain (D) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of SLUG expression in MCF7 (A), mouse heart (B), rat heart (C), rat brain (D) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of SLUG staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of SLUG staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
Uniprot Description
Snail2: Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle. Belongs to the snail C2H2-type zinc-finger protein family.
Protein type: Transcription factor; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Apoptosis
Chromosomal Location of Human Ortholog: 8q11
Cellular Component: cytoplasm; nuclear chromatin; nucleus
Molecular Function: chromatin binding; metal ion binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding
Biological Process: epithelial to mesenchymal transition; negative regulation of cell adhesion mediated by integrin; negative regulation of chondrocyte differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of transcription from RNA polymerase II promoter; neural crest cell development; Notch signaling pathway; osteoblast differentiation; palate development; pigmentation; positive regulation of cell migration; positive regulation of fat cell differentiation; positive regulation of histone acetylation; regulation of chemokine production; regulation of osteoblast differentiation; sensory perception of sound; substrate-bound cell migration, cell release from substrate; transcription, DNA-dependent; white fat cell differentiation; Wnt receptor signaling pathway through beta-catenin
Disease: Piebald Trait; Waardenburg Syndrome, Type 2d
Research Articles on SNAI2
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Product Notes
The SNAI2 snai2 (Catalog #AAA8242278) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SLUG Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SLUG can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200). Researchers should empirically determine the suitability of the SNAI2 snai2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLUG, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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