Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/70.)
Rabbit anti-Human SLC8A3 Polyclonal Antibody | anti-SLC8A3 antibody
SLC8A3 Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/70.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/70.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]
Uniprot Description
Mediates the electrogenic exchange of Ca2+ against Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. Contributes to cellular Ca2+ homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca2+ levels due to release of Ca2+ stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca2+ from the cell during the next phase, so that cytoplasmic Ca2+ levels rapidly return to baseline. Contributes to Ca2+ transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca2+ levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca2+ efflux from mitochondria and contributes to mitochondrial Ca2+ ion homeostasis ().
Research Articles on SLC8A3
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Product Notes
The SLC8A3 slc8a3 (Catalog #AAA9407120) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC8A3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC8A3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:100-1:300. Researchers should empirically determine the suitability of the SLC8A3 slc8a3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC8A3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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