Immunohistochemistry (IHC)
(Rabbit Anti-SLC6A8 AntibodyParaffin Embedded Tissue: Human MuscleCellular Data: Skeletal muscle cellsAntibody Concentration: 4.0-8.0 ug/mlMagnification: 400X)
Rabbit SLC6A8 Polyclonal Antibody | anti-SLC6A8 antibody
SLC6A8 antibody - N-terminal region
Immunohistochemistry (IHC)
(Rabbit Anti-SLC6A8 AntibodyParaffin Embedded Tissue: Human MuscleCellular Data: Skeletal muscle cellsAntibody Concentration: 4.0-8.0 ug/mlMagnification: 400X)
Immunohistochemistry (IHC)
(Rabbit Anti-SLC6A8 AntibodyParaffin Embedded Tissue: Human MuscleCellular Data: Skeletal muscle cellsAntibody Concentration: 4.0-8.0 ug/mlMagnification: 400X)
Western Blot (WB)
(Host: RabbitTarget Name: SLC6A8Sample Tissue: Human MDA-MB-435s, Human THP-1Antibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: SLC6A8Sample Tissue: Human MDA-MB-435s, Human THP-1Antibody Dilution: 1.0ug/ml)
Western Blot (WB)
(WB Suggested Anti-SLC6A8 Antibody Titration: 2.5ug/mlPositive Control: MDA-MB-435S cell lysateSLC6A8 is strongly supported by BioGPS gene expression data to be expressed in Human MDA-MB435 cells)
Western Blot (WB)
(WB Suggested Anti-SLC6A8 Antibody Titration: 2.5ug/mlPositive Control: MDA-MB-435S cell lysateSLC6A8 is strongly supported by BioGPS gene expression data to be expressed in Human MDA-MB435 cells)
Target Description: SLC6A8 is required for the uptake of creatine in muscles and brain.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Description
SLC6A8: Required for the uptake of creatine in muscles and brain. Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome (XL-CDS). XL-CDS causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Transporter, SLC family; Transporter
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: creatine transporter activity; neurotransmitter:sodium symporter activity; creatine:sodium symporter activity
Biological Process: muscle contraction; neurotransmitter transport; transport; sodium ion transport; creatine metabolic process; creatine transport
Disease: Cerebral Creatine Deficiency Syndrome 1
Research Articles on SLC6A8
Similar Products
Product Notes
The SLC6A8 slc6a8 (Catalog #AAA3206268) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC6A8 antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SLC6A8 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the SLC6A8 slc6a8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: CDQLADRRSP VIEFWENKVL RLSGGLEVPG ALNWEVTLCL LACWVLVYFC. It is sometimes possible for the material contained within the vial of "SLC6A8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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