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Immunohistochemistry (IHC) (Anti-SLC5A2 antibody IHC of human kidney, collecting duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit SLC5A2 / SGLT2 Polyclonal Antibody | anti-SLC5A2 antibody

Rabbit Polyclonal to Human SLC5A2 / SGLT2

Gene Names
SLC5A2; SGLT2
Reactivity
Gibbon, Gorilla, Horse, Human, Rat
Predicted Reactivity: Monkey, Mouse, Bat, Bovine, Hamster (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
SLC5A2 / SGLT2; Polyclonal Antibody; Rabbit Polyclonal to Human SLC5A2 / SGLT2; Anti-SLC5A2 / SGLT2 Antibody (C-Terminus) IHC-plus; SLC5A2; Na(+)/glucose cotransporter 2; SGLT2; Sodium-glucose transporter 2; Sodium/glucose cotransporter 2; Human SLC5A2; anti-SLC5A2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Gibbon, Gorilla, Horse, Human, Rat
Predicted Reactivity: Monkey, Mouse, Bat, Bovine, Hamster (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human SLC5A2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
672
Applicable Applications for anti-SLC5A2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (20 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from C-terminus of human SLC5A2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rat, Elephant, Horse (100%); Marmoset, Mouse, Hamster, Bat, Bovine (94%); Dog (88%).
Immunogen Type
Synthetic peptide
Immunogen
SLC5A2 / SGLT2 antibody was raised against synthetic 17 amino acid peptide from C-terminus of human SLC5A2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rat, Elephant, Horse (100%); Marmoset, Mouse, Hamster, Bat, Bovine (94%); Dog (88%); Panda, Rabbit (82%).
Antigen Modification
C-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-SLC5A2 antibody IHC of human kidney, collecting duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-SLC5A2 antibody IHC of human kidney, collecting duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Product Categories/Family for anti-SLC5A2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
49,357 Da
NCBI Official Full Name
sodium/glucose cotransporter 2
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 2
NCBI Official Symbol
SLC5A2
NCBI Official Synonym Symbols
SGLT2
NCBI Protein Information
sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; solute carrier family 5 member 2; low affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose transporter), member 2
UniProt Protein Name
Sodium/glucose cotransporter 2
UniProt Gene Name
SLC5A2
UniProt Synonym Gene Names
SGLT2; Na(+)/glucose cotransporter 2
UniProt Entry Name
SC5A2_HUMAN

NCBI Description

This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. [provided by RefSeq, Sep 2009]

Uniprot Description

SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function: low-affinity glucose:sodium symporter activity

Biological Process: transport; carbohydrate metabolic process; sodium ion transport; glucose transport; transmembrane transport

Disease: Renal Glucosuria

Research Articles on SLC5A2

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Product Notes

The SLC5A2 slc5a2 (Catalog #AAA247749) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human SLC5A2 / SGLT2 reacts with Gibbon, Gorilla, Horse, Human, Rat Predicted Reactivity: Monkey, Mouse, Bat, Bovine, Hamster (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's SLC5A2 / SGLT2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (20 ug/ml). Researchers should empirically determine the suitability of the SLC5A2 slc5a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC5A2 / SGLT2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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