Rabbit anti-Human SLC33A1 Polyclonal Antibody | anti-SLC33A1 antibody

SLC33A1 Antibody

Cat. Num. AAA7049623

• Gene Names: SLC33A1; AT1; AT-1; ACATN; SPG42; CCHLND
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%, Protein G purified
• Synonyms: SLC33A1; Polyclonal Antibody; SLC33A1 Antibody; Acetyl-coenzyme A transporter 1; AT-1; Acetyl-CoA transporter 1; Solute carrier family 33 member 1; ACATN; AT1; anti-SLC33A1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 549

• Applicable Applications for anti-SLC33A1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1: 20-1: 200
• Immunogen: Recombinant Human Acetyl-coenzyme A transporter 1 protein (1-74AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: Non-conjugated
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82471
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human thyroid tissue using MBS7049623 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7049623 at dilution of 1:100)

Western Blot (WB)

(Western BlotPositive WB detected in: A549 whole cell lysate,HepG2 whole cell lysate,Mouse liver tissue,Mouse kidney tissue,Mouse brain tissueAll lanes: SLC33A1 antibody at 2.5ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 61 KDaObserved band size: 50 KDa)

Related Product Information for anti-SLC33A1 antibody

Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed: 9096318). Negatively regulates BMP signaling (PubMed: 25402622).

NCBI and Uniprot Product Information

• NCBI GI #: 300360496
• NCBI GeneID: 9197
• NCBI Accession #: NP_001177921.1
• NCBI GenBank Nucleotide #: NM_001190992.1
• UniProt Accession #: O00400; B2R5Q2; D3DNK4
• Molecular Weight: 60,909 Da
• NCBI Official Full Name: acetyl-coenzyme A transporter 1
• NCBI Official Synonym Full Names: solute carrier family 33 member 1
• NCBI Official Symbol: SLC33A1
• NCBI Official Synonym Symbols: AT1; AT-1; ACATN; SPG42; CCHLND
• NCBI Protein Information: acetyl-coenzyme A transporter 1
• UniProt Protein Name: Acetyl-coenzyme A transporter 1
• Protein Family: Acetyl-coenzyme A transporter
• UniProt Gene Name: SLC33A1
• UniProt Synonym Gene Names: ACATN; AT1; AT-1; Acetyl-CoA transporter 1
• UniProt Entry Name: ACATN_HUMAN

NCBI Description

The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

SLC33A1: Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides. Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Defects in SLC33A1 are the cause of congenital cataracts, hearing loss, and neurodegeneration (CCHLND). CCHLND is an autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin and copper. Brain MRI shows cerebral and cerebellar atrophy and hypomyelination. Belongs to the SLC33A transporter family.

Protein type: Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 3q25.31

Cellular Component: Golgi membrane; integral to plasma membrane; membrane

Molecular Function: acetyl-CoA transporter activity; solute:hydrogen symporter activity

Biological Process: BMP signaling pathway; transmembrane transport; transport

Disease: Congenital Cataracts, Hearing Loss, And Neurodegeneration; Spastic Paraplegia 42, Autosomal Dominant