Rabbit SLC25A6 Polyclonal Antibody | anti-SLC25A6 antibody

SLC25A6 (R155) Polyclonal Antibody

Cat. Num. AAA3004314

• Gene Names: SLC25A6; ANT; AAC3; ANT3; ANT 2; ANT 3; ANT3Y
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: SLC25A6; Polyclonal Antibody; SLC25A6 (R155) Polyclonal Antibody; ADP/ATP translocase 3; ADP; ATP carrier protein 3; ATP carrier protein; isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6; ANT3; ORF Names: CDABP0051; anti-SLC25A6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SLC25A6 (R155) polyclonal antibody detects endogenous levels of SLC25A6 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 298

• Applicable Applications for anti-SLC25A6 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 120-160 of Human SLC25A6.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of SLC25A6 (R155) pAb at 1:1000 dilutionLane1:H1792 whole cell lysate (40ug) Lane2:HepG2 whole cell lysate (40ug) Lane3:The Testis tissue lysate of Mouse (40ug) Lane4:The Testis tissue lysate of Rat (40ug) Lane5:HEK293T whole cell lysate (20ug))

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of SLC25A6 (R155) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.)

Related Product Information for anti-SLC25A6 antibody

ANT2 (adenine nucleotide translocator 2), also known as SLC25A5 (solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5), T2, T3, 2F1 or AAC2, is a 298 amino acid multi-pass membrane protein that localizes to the inner mitochondrial membrane and contains three solcar repeats. Existing as one of the most abundant mitochondrial proteins, ANT2 functions as a homodimer that facilitates the exchange of ADP and ATP between the mitochondrion and the cytosol, thus linking the compartment of ATP production (within the mitochondrion) to the areas of ATP utilization (within the cytosol). Suppression of ANT2 in breast cancer cells results in apoptosis and tumor growth inhibition, suggesting that ANT2 may be involved in carcinogenesis. ANT3 (adenine nucleotide translocator 2) is a 298 amino acid mitochondrial protein that functions in a similar manner to ANT2 but, unlike ANT2, may also play a role in the formation of the permeability transition pore complex (PTPC), a structure that is important for the regulation of apoptosis.

NCBI and Uniprot Product Information

• NCBI GI #: 156071462
• NCBI GeneID: 293
• NCBI Accession #: NP_001627.2
• NCBI GenBank Nucleotide #: NP_001627.2
• UniProt Accession #: P12236
• Molecular Weight: ~ 33kDa
• NCBI Official Full Name: ADP/ATP translocase 3
• NCBI Official Synonym Full Names: solute carrier family 25 member 6
• NCBI Official Symbol: SLC25A6
• NCBI Official Synonym Symbols: ANT; AAC3; ANT3; ANT 2; ANT 3; ANT3Y
• NCBI Protein Information: ADP/ATP translocase 3
• UniProt Protein Name: ADP/ATP translocase 3
• Protein Family: ADP/ATP translocase
• UniProt Gene Name: SLC25A6
• UniProt Synonym Gene Names: ANT3; ANT 2; ANT 3
• UniProt Entry Name: ADT3_HUMAN

NCBI Description

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

Uniprot Description

SLC25A6: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Belongs to the mitochondrial carrier family.

Protein type: Transporter, SLC family; Membrane protein, integral; Mitochondrial; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; nucleus; mitochondrial inner membrane presequence translocase complex

Molecular Function: protein binding; ATP:ADP antiporter activity

Biological Process: ATP transport; ADP transport; cellular protein metabolic process; viral reproduction; apoptosis; active induction of host immune response by virus; virus-host interaction; energy reserve metabolic process; viral infectious cycle; regulation of insulin secretion; protein targeting to mitochondrion; transmembrane transport