Rabbit anti-Human SLC25A6 Polyclonal Antibody | anti-SLC25A6 antibody

SLC25A6, ID (SLC25A6, ANT3, ADP/ATP translocase 3, ADP,ATP carrier protein 3, ADP,ATP carrier protein, isoform T2, Adenine nucleotide translocator 3, Solute carrier family 25 member 6) (Biotin)

Cat. Num. AAA6348277

• Gene Names: SLC25A6; AAC3; ANT3; ANT3Y
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SLC25A6; Polyclonal Antibody; ID (SLC25A6; ANT3; ADP/ATP translocase 3; ADP; ATP carrier protein 3; ATP carrier protein; isoform T2; Adenine nucleotide translocator 3; Solute carrier family 25 member 6) (Biotin); Solute carrier family 25 member 6; anti-SLC25A6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-SLC25A6 antibody: Flow Cytometry (FC/FACS), ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: FC/FACS: 1:10-50; ELISA: 1:1,000; IF: 1:10-50; IHC: 1:10-50; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: SLC25A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-163 amino acids from the Central region of human SLC25A6.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SLC25A6 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SLC25A6 antibody detected the SLC25A6 protein (arrow).)

Immunohistochemistry (IHC)

(SLC25A6 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLC25A6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Immunofluorescence (IF)

(Confocal immunofluorescent analysis of SLC25A6 Antibody (Center) with A549 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)

Flow Cytometry (FC/FACS)

(SLC25A6 Antibody (Center) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-SLC25A6 antibody

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene.

Product Categories/Family for anti-SLC25A6 antibody

Antibodies; Enzymes

References

Danishuddin, M., et al. J Mol Model 16(3):535-541(2010). Hu, Z., et al. FEBS Lett. 583(2):383-388(2009). Yang, Z., et al. Mol. Biol. Cell 18(11):4681-4689(2007). Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007). Jang, J.Y., et al. Cell. Immunol. 241(1):14-25(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 156071462
• NCBI GeneID: 293
• NCBI Accession #: NP_001627.2
• NCBI GenBank Nucleotide #: NM_001636.3
• UniProt Accession #: P12236; Q96C49
• Molecular Weight: 32,866 Da
• NCBI Official Full Name: ADP/ATP translocase 3
• NCBI Official Synonym Full Names: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
• NCBI Official Symbol: SLC25A6
• NCBI Official Synonym Symbols: AAC3; ANT3; ANT3Y
• NCBI Protein Information: ADP/ATP translocase 3; ANT 2; ANT 3; ADP,ATP carrier protein 3; ADP/ATP translocator of liver; ADP,ATP carrier protein, liver; adenine nucleotide translocator 3; solute carrier family 25 member 6; ADP,ATP carrier protein, isoform T2
• UniProt Protein Name: ADP/ATP translocase 3
• Protein Family: ADP/ATP translocase
• UniProt Gene Name: SLC25A6
• UniProt Synonym Gene Names: ANT3; ANT 2; ANT 3
• UniProt Entry Name: ADT3_HUMAN

NCBI Description

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

SLC25A6: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Belongs to the mitochondrial carrier family.

Protein type: Transporter, SLC family; Membrane protein, integral; Mitochondrial; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; nucleus; mitochondrial inner membrane presequence translocase complex

Molecular Function: protein binding; ATP:ADP antiporter activity

Biological Process: ATP transport; ADP transport; cellular protein metabolic process; viral reproduction; apoptosis; active induction of host immune response by virus; virus-host interaction; energy reserve metabolic process; viral infectious cycle; regulation of insulin secretion; protein targeting to mitochondrion; transmembrane transport