Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Mouse heart tissue Amount of lysate: 40ug per lane Primary antibody: 1/1000 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 minutes)
Rabbit SLC24A1 Polyclonal Antibody | anti-SLC24A1 antibody
SLC24A1 Antibody
Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Mouse heart tissue Amount of lysate: 40ug per lane Primary antibody: 1/1000 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 minutes)
Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Mouse heart tissue Amount of lysate: 40ug per lane Primary antibody: 1/1000 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 minutes)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
SLC24A1: Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Defects in SLC24A1 are the cause of congenital stationary night blindness type 1D (CSNB1D). An autosomal recessive form of congenital stationary night blindness a non- progressive retinal disorder characterized by impaired night vision. CSNB1D is characterized by a Riggs type of electroretinogram (proportionally reduced a- and b-waves). Patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus. Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q22
Cellular Component: membrane; outer membrane; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; calcium, potassium:sodium antiporter activity; symporter activity
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; visual perception; transport; calcium ion transport; response to light intensity; ion transport; transmembrane transport
Disease: Night Blindness, Congenital Stationary, Type 1d
Research Articles on SLC24A1
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Product Notes
The SLC24A1 slc24a1 (Catalog #AAA9406963) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC24A1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SLC24A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:200-1:1000. Researchers should empirically determine the suitability of the SLC24A1 slc24a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC24A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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