Rabbit SLC22A8 Polyclonal Antibody | anti-SLC22A8 antibody

SLC22A8 (Solute Carrier Family 22 Member 8, Organic Anion Transporter 3, OAT3) (FITC)

Cat. Num. AAA6437862

• Gene Names: SLC22A8; OAT3
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: SLC22A8; Polyclonal Antibody; SLC22A8 (Solute Carrier Family 22 Member 8; Organic Anion Transporter 3; OAT3) (FITC); anti-SLC22A8 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes SLC22A8. Species Crossreactivity: human, mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-SLC22A8 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:25-1:100; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to human SLC22A8.
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of extracts of 231 cell line, using SLC22A8 antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human breast cancer tissue using SLC22A8 antibody.)

Product Categories/Family for anti-SLC22A8 antibody

Antibodies; Ion Transport

NCBI and Uniprot Product Information

• NCBI GI #: 74730587
• NCBI GeneID: 9376
• UniProt Accession #: Q8TCC7; O95820; Q59EW9; Q96TC1; B4DPH7; F5GWA8; F5H5J1
• Molecular Weight: 542
• NCBI Official Full Name: Solute carrier family 22 member 8
• NCBI Official Synonym Full Names: solute carrier family 22 (organic anion transporter), member 8
• NCBI Official Symbol: SLC22A8
• NCBI Official Synonym Symbols: OAT3
• NCBI Protein Information: solute carrier family 22 member 8; hOAT3; organic anion transporter 3
• UniProt Protein Name: Solute carrier family 22 member 8
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC22A8
• UniProt Synonym Gene Names: OAT3; hOAT3
• UniProt Entry Name: S22A8_HUMAN

NCBI Description

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]

Uniprot Description

SLC22A8: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q11

Cellular Component: basolateral plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein kinase C binding; inorganic anion exchanger activity; organic anion transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity

Biological Process: quaternary ammonium group transport; response to toxin; response to methotrexate; transmembrane transport