Goat SLC22A17 Polyclonal Antibody | anti-SLC22A17 antibody
Goat anti-SLC22A17 Antibody
Western Blot: Preliminary experiments gave an approx 150kDa band in Human Cerebellum lysates after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 57.7kDa according to NP_065105.2. The 150kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
Uniprot Description
SLC22A17: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: integral to plasma membrane; plasma membrane; vacuolar membrane
Molecular Function: organic anion transmembrane transporter activity; transmembrane receptor activity; transmembrane transporter activity
Biological Process: cellular iron ion homeostasis; organic anion transport; siderophore transport; signal transduction; transmembrane transport
Research Articles on SLC22A17
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Product Notes
The SLC22A17 slc22a17 (Catalog #AAA421746) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-SLC22A17 Antibody reacts with Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's SLC22A17 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Preliminary experiments gave an approx 150kDa band in Human Cerebellum lysates after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 57.7kDa according to NP_065105.2. The 150kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the SLC22A17 slc22a17 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: PETKRKLLPE VLRD. It is sometimes possible for the material contained within the vial of "SLC22A17, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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