Rabbit anti-Human SLC22A16 Polyclonal Antibody | anti-SLC22A16 antibody

Anti-SLC22A16 Antibody (aa101-150) IHC-plus

Cat. Num. AAA2400301

• Gene Names: SLC22A16; CT2; OAT6; OCT6; OKB1; FLIPT2; HEL-S-18; dJ261K5.1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Protein A purified
• Synonyms: SLC22A16; Polyclonal Antibody; Anti-SLC22A16 Antibody (aa101-150) IHC-plus; Rabbit Polyclonal (IgG) to Human SLC22A16; Human SLC22A16; Carnitine transporter 2; CT2; Flipt 2; FLIPT2; OKB1; OCT6; WUGSC:RG331P03.1; DJ261K5.1; OAT6; Organic cation transporter 6; anti-SLC22A16 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human SLC22A16
• Purity/Purification: Protein A purified
• Form/Format: Lyophilized from PBS with 2% sucrose
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 577

• Applicable Applications for anti-SLC22A16 antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IHC-P (10 ug/ml); WB (2.5 ug/ml)
• Immunogen: SLC22A16 antibody was raised against synthetic peptide located between aa101-150 of human SLC22A16 (Q96RU0, NP_149116). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Gibbon, Monkey (92%).
• Immunogen Description: Synthetic peptide located between aa101-150 of human SLC22A16 (Q96RU0, NP_149116). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Gibbon, Monkey (92%).
• Resuspension Liquid Description: After adding water, will consist of PBS buffer with 2% sucrose
• Antigen Modification: aa101-150
• Target Species: Human
• Preparation and Storage: Long term: -20 degree C, the use of 50% glycerol is recommended if storing aliquots in -20 degree C for long term use (up to 1 year).; Short term (less than one week): 4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-SLC22A16 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-SLC22A16 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Western Blot (WB)

(SLC22A16 antibody western blot of HepG2 cell lysate.)

Related Product Information for anti-SLC22A16 antibody

SLC22A16 Antibody, Carnitine transporter 2 Antibody, CT2 Antibody, Flipt 2 Antibody, FLIPT2 Antibody, OKB1 Antibody, OCT6 Antibody, WUGSC:RG331P03.1 Antibody, DJ261K5.1 Antibody, OAT6 Antibody, Organic cation transporter 6 Antibody Description: High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.

NCBI and Uniprot Product Information

• NCBI GI #: 31542327
• NCBI GeneID: 85413
• NCBI Accession #: NP_149116.2
• NCBI GenBank Nucleotide #: NM_033125.3
• UniProt Accession #: Q86VW1; O14567; Q5JXM1; Q8IUG8; Q8IZD5; Q96M90; Q96RU0
• Molecular Weight: 58,061 Da
• NCBI Official Full Name: solute carrier family 22 member 16
• NCBI Official Synonym Full Names: solute carrier family 22 (organic cation/carnitine transporter), member 16
• NCBI Official Symbol: SLC22A16
• NCBI Official Synonym Symbols: CT2; OAT6; OCT6; OKB1; FLIPT2; HEL-S-18; dJ261K5.1
• NCBI Protein Information: solute carrier family 22 member 16
• UniProt Protein Name: Solute carrier family 22 member 16
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC22A16
• UniProt Synonym Gene Names: OCT6; CT2; FLIPT2; Flipt 2
• UniProt Entry Name: S22AG_HUMAN

NCBI Description

This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

Uniprot Description

SLC22A16: High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q22.1|6q21-q22.1

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: amine transmembrane transporter activity; carnitine transporter activity; organic cation transmembrane transporter activity

Biological Process: acid secretion; amine transport; carnitine transport; cell differentiation; multicellular organismal development; organic cation transport; single fertilization; sperm motility; spermatogenesis; transmembrane transport