Rabbit anti-Human SLC22A12 Polyclonal Antibody | anti-SLC22A12 antibody

SLC22A12 (Solute Carrier Family 22 Member 12, Organic Anion Transporter 4-like Protein, Renal-specific Transporter, RST, Urate Anion Exchanger 1, OATL4, URAT1, UNQ6453/PRO34004) (HRP)

Cat. Num. AAA6394271

• Gene Names: SLC22A12; RST; OAT4L; URAT1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SLC22A12; Polyclonal Antibody; SLC22A12 (Solute Carrier Family 22 Member 12; Organic Anion Transporter 4-like Protein; Renal-specific Transporter; RST; Urate Anion Exchanger 1; OATL4; URAT1; UNQ6453/PRO34004) (HRP); anti-SLC22A12 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SLC22A12.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Sequence Length: 553

• Applicable Applications for anti-SLC22A12 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human SLC22A12, aa1-553 (NP_653186.2).
• Immunogen Sequence: MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of SLC22A12 expression in transfected 293T cell line by SLC22A12 polyclonal antibody. Lane 1: SLC22A12 transfected lysate (59.6kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-SLC22A12 antibody

Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.

Product Categories/Family for anti-SLC22A12 antibody

Antibodies; Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 24497485
• NCBI GeneID: 116085
• NCBI Accession #: NP_653186.2
• NCBI GenBank Nucleotide #: NM_144585.2
• UniProt Accession #: Q96S37
• NCBI Official Full Name: solute carrier family 22 member 12 isoform a
• NCBI Official Synonym Full Names: solute carrier family 22 member 12
• NCBI Official Symbol: SLC22A12
• NCBI Official Synonym Symbols: RST; OAT4L; URAT1
• NCBI Protein Information: solute carrier family 22 member 12
• UniProt Protein Name: Solute carrier family 22 member 12
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC22A12
• UniProt Synonym Gene Names: OATL4; URAT1; RST
• UniProt Entry Name: S22AC_HUMAN

NCBI Description

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Description

SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: brush border membrane; apical plasma membrane; integral to membrane; plasma membrane

Molecular Function: urate transmembrane transporter activity; PDZ domain binding

Biological Process: response to drug; urate transport; urate metabolic process; cellular homeostasis; organic acid transport; transmembrane transport

Disease: Hypouricemia, Renal, 1