Western Blot (WB)
(mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS7604152 (SLC22A1 Antibody) at dilution of 1:600)
Rabbit SLC22A1 Polyclonal Antibody | anti-SLC22A1 antibody
SLC22A1 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS7604152 (SLC22A1 Antibody) at dilution of 1:600)
Western Blot (WB)
(mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS7604152 (SLC22A1 Antibody) at dilution of 1:600)
NCBI and Uniprot Product Information
Uniprot Description
SLC22A1: Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral
Cellular Component: basolateral plasma membrane; integral to membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: acetylcholine transmembrane transporter activity; dopamine transmembrane transporter activity; identical protein binding; monoamine transmembrane transporter activity; norepinephrine transmembrane transporter activity; organic cation transmembrane transporter activity; protein homodimerization activity; quaternary ammonium group transmembrane transporter activity; secondary active organic cation transmembrane transporter activity; transmembrane transporter activity; transporter activity
Biological Process: cation transport; dopamine transport; epinephrine transport; establishment and/or maintenance of transmembrane electrochemical gradient; ion transport; monoamine transport; multidrug transport; neurotransmitter transport; norepinephrine transport; organic cation transport; protein homooligomerization; quaternary ammonium group transport; transmembrane transport; transport
Research Articles on SLC22A1
Similar Products
Product Notes
The SLC22A1 slc22a1 (Catalog #AAA7604152) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC22A1 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SLC22A1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the SLC22A1 slc22a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC22A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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