Western Blot (WB)
(Western Blot analysis of SKIV2L2 polyclonal antibody)
Rabbit anti-Human, Mouse SKIV2L2 Polyclonal Antibody | anti-SKIV2L2 antibody
SKIV2L2 Polyclonal Antibody
Gene Names
MTREX; Dob1; Mtr4; SKIV2L2; fSAP118; KIAA0052
Reactivity
Human, Mouse
Applications
Western Blot, Immunohistochemistry, Immunoprecipitation
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
SKIV2L2 ; Polyclonal Antibody; SKIV2L2 Polyclonal Antibody; Superkiller viralicidic activity 2-like 2; ATP-dependent RNA helicase SKIV2L2; TRAMP-like complex helicase; SKIV2L2; KIAA0052; Mtr4; anti-SKIV2L2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
SKIV2L2 polyclonal antibody detects endogenous levels of SKIV2L2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
1042
Applicable Applications for anti-SKIV2L2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IP: 1:50-1:200
IHC: 1:50-1:200
IP: 1:50-1:200
Immunogen
Recombinant full length Human SKIV2L2.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot analysis of SKIV2L2 polyclonal antibody)
Western Blot (WB)
(Western Blot analysis of SKIV2L2 polyclonal antibody)
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analysis of SKIV2L2 polyclonal antibody in paraffin-embedded Human Rectal Cancer tissue.)
Immunohistochemistry (IHC)
(Immunohistochemistry (IHC) analysis of SKIV2L2 polyclonal antibody in paraffin-embedded Human Rectal Cancer tissue.)
Related Product Information for anti-SKIV2L2 antibody
SKIV2L2 (superkiller viralicidic activity 2-like 2) is a 1, 042 amino acid protein that belongs to the helicase family and the SKI2 subfamily. The SKIV2L2 protein localizes to nucleus, contains one helicase ATP-binding domain and one helicase C-terminal domain. SKIV2L2 is identified in the spliceosome C complex and may be involved in pre-mRNA splicing. SKIV2L2 is associated with the RNA exosome complex and involved in the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA. The SKIV2L2 gene is conserved in chimpanzee, canine, bovine, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C. elegans, S. pombe, S. cerevisiae, K. lactis, E. gossypii, M. grisea, N. crassa, A. thaliana and rice, and maps to human chromosome 5q11.2. A mutation in SKIV2L2 in zebrafish causes defects in cell proliferation, suggesting that SKIV2L2 plays a role in regulating melanoblast proliferation during early stages of melanocyte regeneration.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
~118kDa
NCBI Official Full Name
Exosome RNA helicase MTR4
NCBI Official Synonym Full Names
Mtr4 exosome RNA helicase
NCBI Official Symbol
MTREX
NCBI Official Synonym Symbols
Dob1; Mtr4; SKIV2L2; fSAP118; KIAA0052
NCBI Protein Information
exosome RNA helicase MTR4
UniProt Protein Name
Superkiller viralicidic activity 2-like 2
UniProt Gene Name
SKIV2L2
UniProt Synonym Gene Names
KIAA0052; Mtr4
UniProt Entry Name
SK2L2_HUMAN
Uniprot Description
SKIV2L2: May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Belongs to the helicase family. SKI2 subfamily.
Protein type: Spliceosome; EC 3.6.4.13; Nucleolus; DNA-binding; Helicase
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: nucleoplasm; nucleolus; exosome (RNase complex); nucleus
Molecular Function: protein binding; helicase activity; ATP binding
Biological Process: nuclear mRNA splicing, via spliceosome; maturation of 5.8S rRNA
Research Articles on SKIV2L2
Similar Products
Product Notes
The SKIV2L2 skiv2l2 (Catalog #AAA3011209) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SKIV2L2 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SKIV2L2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP). WB: 1:500-1:2000 IHC: 1:50-1:200 IP: 1:50-1:200. Researchers should empirically determine the suitability of the SKIV2L2 skiv2l2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SKIV2L2 , Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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