Western Blot (WB)
(SKAP1 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the SKAP1 antibody detected the SKAP1 protein (arrow).)
Rabbit anti-Human SKAP1 Polyclonal Antibody | anti-SKAP1 antibody
SKAP1 Antibody (C-term)
Western Blot (WB)
(SKAP1 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the SKAP1 antibody detected the SKAP1 protein (arrow).)
Western Blot (WB)
(SKAP1 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the SKAP1 antibody detected the SKAP1 protein (arrow).)
intracellular molecules with modular domains capable of recruiting
additional proteins but that exhibit no intrinsic enzymatic
activity. The encoded protein contains a unique N-terminal region
followed by a PH domain and C-terminal SH3 domain. Along with the
adhesion and degranulation-promoting adaptor protein, the encoded
protein plays a critical role in inside-out signaling by coupling
T-cell antigen receptor stimulation to the activation of integrins.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Raab, M., et al. Immunity 32(4):541-556(2010)
Lehmann, R., et al. Proteomics 9(23):5288-5295(2009)
Fang, L., et al. Cell Cycle 8(17):2819-2827(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]
Uniprot Description
SKAP55: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. Belongs to the SKAP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: cytoplasm; plasma membrane; intercellular junction; nucleus
Molecular Function: protein binding; SH3/SH2 adaptor activity; protein complex binding; SH2 domain binding; protein phosphatase binding; SH3 domain binding; protein kinase binding
Biological Process: positive regulation of signal transduction; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway
Research Articles on SKAP1
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Product Notes
The SKAP1 skap1 (Catalog #AAA9201190) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 266-295. The SKAP1 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SKAP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SKAP1 skap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SKAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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