Western Blot (WB)
(SIRT4 Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the SIRT4 antibody detected the SIRT4 protein (arrow).)
Rabbit SIRT4 Polyclonal Antibody | anti-SIRT4 antibody
SIRT4 Antibody (N-term)
Western Blot (WB)
(SIRT4 Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the SIRT4 antibody detected the SIRT4 protein (arrow).)
Western Blot (WB)
(SIRT4 Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the SIRT4 antibody detected the SIRT4 protein (arrow).)
proteins, homologs to the yeast Sir2 protein. Members of the
sirtuin family are characterized by a sirtuin core domain and
grouped into four classes. The functions of human sirtuins have not
yet been determined; however, yeast sirtuin proteins are known to
regulate epigenetic gene silencing and suppress recombination of
rDNA. Studies suggest that the human sirtuins may function as
intracellular regulatory proteins with mono-ADP-ribosyltransferase
activity. The protein encoded by this gene is included in class IV
of the sirtuin family.
Ahuja, N., et al. J. Biol. Chem. 282(46):33583-33592(2007)
Yamamoto, H., et al. Mol. Endocrinol. 21(8):1745-1755(2007)
Haigis, M.C., et al. Cell 126(5):941-954(2006)
Scherer, S.E., et al. Nature 440(7082):346-351(2006)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Uniprot Description
SIRT4: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down- regulates insulin secretion. Has no detectable protein deacetylase activity. Belongs to the sirtuin family. Class II subfamily.
Protein type: Tumor suppressor; EC 3.5.1.-; Deacetylase; EC 2.4.2.-; Mitochondrial
Chromosomal Location of Human Ortholog: 12q
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: protein binding; zinc ion binding; NAD+ ADP-ribosyltransferase activity
Biological Process: protein amino acid ADP-ribosylation; chromatin silencing; glutamine metabolic process; positive regulation of lipid biosynthetic process; response to DNA damage stimulus; negative regulation of fatty acid oxidation; negative regulation of insulin secretion
Research Articles on SIRT4
Similar Products
Product Notes
The SIRT4 sirt4 (Catalog #AAA9204337) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 67-95. The SIRT4 Antibody (N-term) reacts with Human, mouse (Predicted Reactivity: Bovine) and may cross-react with other species as described in the data sheet. AAA Biotech's SIRT4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SIRT4 sirt4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIRT4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
