Rabbit anti-Human SIRPG Polyclonal Antibody | anti-SIRPG antibody

SIRPG, ID (SIRPG, SIRPB2, Signal-regulatory protein gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, CD172g) (PE)

Cat. Num. AAA6347790

• Gene Names: SIRPG; CD172g; SIRPB2; SIRP-B2; FLJ42230; bA77C3.1; SIRPgamma
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SIRPG; Polyclonal Antibody; ID (SIRPG; SIRPB2; Signal-regulatory protein gamma; CD172 antigen-like family member B; Signal-regulatory protein beta-2; CD172g) (PE); CD172g; anti-SIRPG antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-SIRPG antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SIRPG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-221 amino acids from the Central region of human SIRPG.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SIRPG Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SIRPG antibody detected the SIRPG protein (arrow).)

Related Product Information for anti-SIRPG antibody

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.

Product Categories/Family for anti-SIRPG antibody

Antibodies; CD Markers

References

Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009). Kawasaki, M., et al. Clin. Exp. Rheumatol. 27(2):260-266(2009). Stefanidakis, M., et al. Blood 112(4):1280-1289(2008). Lamesch, P., et al. Genomics 89(3):307-315(2007). Barclay, A.N., et al. Nat. Rev. Immunol. 6(6):457-464(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 94538337
• NCBI GeneID: 55423
• NCBI Accession #: NP_543006.2; NP_001034597.1
• NCBI GenBank Nucleotide #: NM_080816.2
• UniProt Accession #: Q9P1W8; Q5D051; Q5JV25; Q5MKL4; Q8WWA5; Q9NQK8; B1AKP6
• Molecular Weight: 42,498 Da
• NCBI Official Full Name: signal-regulatory protein gamma isoform 2
• NCBI Official Synonym Full Names: signal-regulatory protein gamma
• NCBI Official Symbol: SIRPG
• NCBI Official Synonym Symbols: CD172g; SIRPB2; SIRP-B2; FLJ42230; bA77C3.1; SIRPgamma
• NCBI Protein Information: signal-regulatory protein gamma; SIRP-gamma; SIRP beta 2; SIRP-beta-2; CD172g antigen; OTTHUMP00000029998; OTTHUMP00000029999; OTTHUMP00000030000; OTTHUMP00000185041; signal-regulatory protein beta 2; signal-regulatory protein beta-2; CD172 antigen-like f
• UniProt Protein Name: Signal-regulatory protein gamma
• Protein Family: Signal-regulatory protein
• UniProt Gene Name: SIRPG
• UniProt Synonym Gene Names: SIRPB2; SIRP-gamma; SIRP-b2; SIRP-beta-2
• UniProt Entry Name: SIRPG_HUMAN

NCBI Description

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]

Uniprot Description

SIRPG: Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; cell-cell signaling; positive regulation of cell proliferation; positive regulation of cell-cell adhesion; positive regulation of T cell activation; cell adhesion; blood coagulation; leukocyte migration