Immunohistochemistry (IHC)
(SIK2/SNF1LK2 (5ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human adrenal, followed by biotinylated goat, rabbit IgG, alkaline phosphatase-streptavidin and chromogen)
Rabbit anti-Human SIK2 Polyclonal Antibody | anti-SIK2 antibody
SIK2, ID (SIK2, KIAA0781, QIK, SNF1LK2, Salt-inducible kinase 2)
Gene Names
SIK2; QIK; SNF1LK2; LOH11CR1I
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
SIK2; Polyclonal Antibody; ID (SIK2; KIAA0781; QIK; SNF1LK2; Salt-inducible kinase 2); Anti -SIK2; anti-SIK2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Recognizes human SIK2/SNF1LK2.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Applicable Applications for anti-SIK2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Suitable for use in Western Blot an Immunohistochemistry.
Dilution: Western Blot: 1-2ug/ml
Immunohistochemistry (Paraffin): 5ug/ml
Dilution: Western Blot: 1-2ug/ml
Immunohistochemistry (Paraffin): 5ug/ml
Immunogen
Synthetic peptide corresponding to human SIK2/SNF1LK2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunohistochemistry (IHC)
(SIK2/SNF1LK2 (5ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human adrenal, followed by biotinylated goat, rabbit IgG, alkaline phosphatase-streptavidin and chromogen)
Immunohistochemistry (IHC)
(SIK2/SNF1LK2 (5ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human adrenal, followed by biotinylated goat, rabbit IgG, alkaline phosphatase-streptavidin and chromogen)
Related Product Information for anti-SIK2 antibody
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Product Categories/Family for anti-SIK2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
103,915 Da
NCBI Official Full Name
serine/threonine-protein kinase SIK2
NCBI Official Synonym Full Names
salt-inducible kinase 2
NCBI Official Symbol
SIK2
NCBI Official Synonym Symbols
QIK; SNF1LK2; LOH11CR1I
NCBI Protein Information
serine/threonine-protein kinase SIK2; SIK-2; SNF1-like kinase 2; qin-induced kinase; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SNF1-like kinase 2
UniProt Protein Name
Serine/threonine-protein kinase SIK2
Protein Family
UniProt Gene Name
SIK2
UniProt Synonym Gene Names
KIAA0781; QIK; SNF1LK2; SIK-2
UniProt Entry Name
SIK2_HUMAN
Uniprot Description
Function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Ref.9
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Magnesium.
Enzyme regulation: Activated by phosphorylation on Thr-175. Ref.1
Subunit structure: Interacts with and phosphorylates TORC2/CRTC2. Ref.9
Subcellular location: Cytoplasm
By similarity.
Post-translational modification: Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Ref.1
Sequence similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.Contains 1 protein kinase domain.Contains 1 UBA domain.
Sequence caution: The sequence BAA34501.3 differs from that shown. Reason: Erroneous initiation.
Research Articles on SIK2
Similar Products
Product Notes
The SIK2 sik2 (Catalog #AAA648811) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIK2, ID (SIK2, KIAA0781, QIK, SNF1LK2, Salt-inducible kinase 2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SIK2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot an Immunohistochemistry. Dilution: Western Blot: 1-2ug/ml Immunohistochemistry (Paraffin): 5ug/ml. Researchers should empirically determine the suitability of the SIK2 sik2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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