Western Blot (WB)
(Western blot analysis of SIK2 in SW480 cell lysate with SIK2 antibody at 1 ug/mL.)
Rabbit SIK2 Polyclonal Antibody | anti-SIK2 antibody
SIK2 Antibody
Western Blot (WB)
(Western blot analysis of SIK2 in SW480 cell lysate with SIK2 antibody at 1 ug/mL.)
Western Blot (WB)
(Western blot analysis of SIK2 in SW480 cell lysate with SIK2 antibody at 1 ug/mL.)
NCBI and Uniprot Product Information
Uniprot Description
QIK: a serine/threonine kinase of the CAMKL family and related to AMPK. Specifically expressed in adipose tissues. Like AMPK, QIK is phosphorylated and activated by LKB1. Part of a molecular complex including TORC2 and calcineurin that regulates the effects of circulating glucose and gut hormones during feeding on TORC2-mediated gene expression. In mice, insulin promotes the phosphorylation and ubiquitin-dependent degradation of TORC2, inhibiting gluconeogenic gene expression during re-feeding. In response to insulin, Akt2 phosphorylates and activates QIK which in turn stimulates the phosphorylation and cytoplasmic translocation of TORC2 where it associates with COP1, which promotes its ubiquitination and proteasomal degradation. Phosphorylates Ser794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CAMK; EC 2.7.11.1; CAMK group; CAMKL family; QIK subfamily
Chromosomal Location of Human Ortholog: 11q23.1
Cellular Component: cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding
Biological Process: regulation of insulin receptor signaling pathway; protein amino acid autophosphorylation; insulin receptor signaling pathway; protein amino acid phosphorylation
Research Articles on SIK2
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Product Notes
The SIK2 sik2 (Catalog #AAA9408046) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIK2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SIK2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the SIK2 sik2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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