Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Signal Transducing Adaptor Protein 1 (STAP1) Polyclonal Antibody | anti-STAP1 antibody
Polyclonal Antibody to Signal Transducing Adaptor Protein 1 (STAP1)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLVKRSDHQ EYKHYWTELR GTTLFFYTDK KSTIYVGKLD IIDLVCLTGQ HSTEKNCAKF TLVLPKEEVH VKTENTESGE EWRGFILTVT ELTVPQHVSL LPGQVIRLHE VLEREKKRRI ETDQLPLMPP EKEKEPVQDY ADVLNPLPEC FYAVSRKEAT AMLEKNPSWG NMILRPGSDS KNYSITIRQE IEMPRIKHFK VTRTGNNYTI ELEKPVTLPN LFSVIDYFVK
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
NCBI and Uniprot Product Information
Uniprot Description
STAP1: an adaptor protein which contains pleckstrin homology (PH) and Src homology 2-like (SRC) domains and a proline-rich region. Induced in activated bone marrow-derived macrophages, and by CpG, LPS, and interferon in myeloid cell lines. Induces pro-inflammatory responses and may contribute to neuronal apoptosis and degeneration. Overexpressed, it interacts with the CSFR, inhibiting its ligand-dependent phosphorylation. Its expression inhibits cellular migration and can increase cytotoxicity against 661W photoreceptor like cells.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5|5 E1
Cellular Component: cytoplasm; intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus; protein complex
Molecular Function: macrophage colony-stimulating factor receptor binding; phosphotyrosine binding; protein binding; protein kinase binding; receptor tyrosine kinase binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: myeloid cell differentiation; negative regulation of macrophage chemotaxis; negative regulation of macrophage colony-stimulating factor signaling pathway; negative regulation of microglial cell migration; negative regulation of phosphorylation; negative regulation of ruffle assembly; positive regulation of actin cytoskeleton reorganization; positive regulation of B cell receptor signaling pathway; positive regulation of gene expression; positive regulation of microglial cell activation; positive regulation of microglial cell mediated cytotoxicity; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of phagocytosis, engulfment; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on STAP1
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Product Notes
The STAP1 stap1 (Catalog #AAA2017922) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Signal Transducing Adaptor Protein 1 (STAP1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Signal Transducing Adaptor Protein 1 (STAP1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the STAP1 stap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLVKRSDHQ EYKHYWTELR GTTLFFYTDK KSTIYVGKLD IIDLVCLTGQ HSTEKNCAKF TLVLPKEEVH VKTENTESGE EWRGFILTVT ELTVPQHVSL LPGQVIRLHE VLEREKKRRI ETDQLPLMPP EKEKEPVQDY ADVLNPLPEC FYAVSRKEAT AMLEKNPSWG NMILRPGSDS KNYSITIRQE IEMPRIKHFK VTRTGNNYTI ELEKPVTLPN LFSVIDYFVK. It is sometimes possible for the material contained within the vial of "Signal Transducing Adaptor Protein 1 (STAP1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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