Western Blot (WB)
(Western Blot: Sample: Rat Serum; Primary Ab: 2ug/mL Rabbit Anti-Rat STAT3 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Rabbit anti-Rat Signal Transducer And Activator Of Transcription 3 (STAT3) Polyclonal Antibody | anti-STAT3 antibody
Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3)
MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-GYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Rat Serum; Primary Ab: 2ug/mL Rabbit Anti-Rat STAT3 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Rat Serum; Primary Ab: 2ug/mL Rabbit Anti-Rat STAT3 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Recombinant STAT3, Rat.)
Western Blot (WB)
(Western Blot: Sample: Recombinant STAT3, Rat.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded Kidney tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded Kidney tissue))
NCBI and Uniprot Product Information
NCBI Description
transcription factor that plays a role in induction of gene expression during acute phase response [RGD, Feb 2006]
Uniprot Description
STAT3: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 10q31
Cellular Component: cytoplasm; cytosol; mitochondrial inner membrane; mitochondrion; nuclear chromatin; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription factor complex
Molecular Function: CCR5 chemokine receptor binding; chromatin DNA binding; DNA binding; DNA binding transcription factor activity; glucocorticoid receptor binding; identical protein binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process: acute-phase response; aging; astrocyte differentiation; cell proliferation; cellular response to cytokine stimulus; cellular response to hormone stimulus; cellular response to leptin stimulus; cellular response to organic cyclic compound; eating behavior; eye photoreceptor cell differentiation; glucose homeostasis; inflammatory response; interleukin-6-mediated signaling pathway; intracellular receptor signaling pathway; JAK-STAT cascade; leptin-mediated signaling pathway; miRNA mediated inhibition of translation; mRNA transcription from RNA polymerase II promoter; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of glycolytic process; negative regulation of hydrogen peroxide biosynthetic process; negative regulation of neuron death; negative regulation of neuron migration; negative regulation of stem cell differentiation; phosphorylation; positive regulation of ATP biosynthetic process; positive regulation of cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of gene silencing by miRNA; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of metalloendopeptidase activity; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein import into nucleus; radial glial cell differentiation; regulation of cell cycle; regulation of mitochondrial membrane permeability; regulation of multicellular organism growth; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to cytokine; response to drug; response to estradiol; response to ethanol; response to leptin; response to organic cyclic compound; response to organic substance; response to peptide hormone; sexual reproduction; stem cell maintenance; T-helper 17 cell lineage commitment; thermoregulation; transcription from RNA polymerase II promoter
Research Articles on STAT3
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Product Notes
The STAT3 stat3 (Catalog #AAA2014890) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Signal Transducer And Activator Of Transcription 3 (STAT3) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Signal Transducer And Activator Of Transcription 3 (STAT3) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the STAT3 stat3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and GST-tag and its sequence is listed below. MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-GYK IM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN. It is sometimes possible for the material contained within the vial of "Signal Transducer And Activator Of Transcription 3 (STAT3), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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