Western Blot (WB)
(Western blot analysis of SHIP1 expression in Raji (A), THP1 (B), NIH3T3 (C) whole cell lysates.)
Rabbit SHIP1 Polyclonal Antibody | anti-INPP5D antibody
Anti-SHIP1 Antibody
Western Blot (WB)
(Western blot analysis of SHIP1 expression in Raji (A), THP1 (B), NIH3T3 (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of SHIP1 expression in Raji (A), THP1 (B), NIH3T3 (C) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Description
SHIP: an SH2-containing inositol phosphatase. A hemopoietic-specific phosphatase that regulates cell survival, growth, cell cycle arrest and apoptosis. Hydrolyzes Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3. A cytosolic protein with a SH2 domain in its N-terminus and two NPXY Shc binding motifs at its C-terminus. Upon receptor cross-linking, SHIP is first recruited to the plasma membrane by its SH2, followed by tyrosine phosphorylation on the NPXY motif. Both membrane relocalization and phosphorylation are essential for its regulatory function. Associates with SHC after cytokine stimulation.
Protein type: Phosphatase, lipid; Motility/polarity/chemotaxis; EC 3.1.3.86
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: cytoskeleton; cytosol; lipid raft; plasma membrane
Molecular Function: inositol-polyphosphate 5-phosphatase activity; protein binding; PTB domain binding; SH3 domain binding
Biological Process: apoptosis; blood coagulation; determination of adult life span; immunoglobulin mediated immune response; inositol phosphate metabolic process; leukocyte migration; negative regulation of B cell proliferation; negative regulation of bone resorption; negative regulation of immune response; negative regulation of interleukin-6 biosynthetic process; negative regulation of monocyte differentiation; negative regulation of neutrophil differentiation; negative regulation of osteoclast differentiation; negative regulation of signal transduction; phosphate metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; phospholipid metabolic process; positive regulation of apoptosis; positive regulation of B cell differentiation; positive regulation of erythrocyte differentiation; signal transduction; T cell receptor signaling pathway
Research Articles on INPP5D
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Product Notes
The INPP5D inpp5d (Catalog #AAA8242052) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SHIP1 Antibody reacts with Human, Mouse, Rat, Bovine and may cross-react with other species as described in the data sheet. AAA Biotech's SHIP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: (1/500 - 1/1000). Researchers should empirically determine the suitability of the INPP5D inpp5d for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHIP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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