Rabbit anti-Human SHFM1 Polyclonal Antibody | anti-SHFM1 antibody
SHFM1 Antibody; HRP conjugated
Gene Names
SHFM1; ECD; DSS1; SEM1; SHFD1; SHSF1; Shfdg1
Reactivity
Human
Applications
ELISA
Purity
>95%,Protein G purified
Synonyms
SHFM1; Polyclonal Antibody; SHFM1 Antibody; HRP conjugated; 26S proteasome complex subunit DSS1; Deleted in split hand/split foot protein 1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 protein; DSS1; SHFDG1; anti-SHFM1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>95%,Protein G purified
Form/Format
Liquid
Sequence Length
70
Applicable Applications for anti-SHFM1 antibody
ELISA (EIA)
Immunogen
Recombinant human 26S proteasome complex subunit DSS1 protein
Conjugation
HRP
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5736 / sc-5733 / sc-28848
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
Related Product Information for anti-SHFM1 antibody
Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
8,278 Da
NCBI Official Full Name
26S proteasome complex subunit DSS1
NCBI Official Synonym Full Names
split hand/foot malformation (ectrodactyly) type 1
NCBI Official Symbol
SHFM1
NCBI Official Synonym Symbols
ECD; DSS1; SEM1; SHFD1; SHSF1; Shfdg1
NCBI Protein Information
26S proteasome complex subunit DSS1
UniProt Protein Name
26S proteasome complex subunit DSS1
Protein Family
UniProt Gene Name
SHFM1
UniProt Synonym Gene Names
DSS1; SHFDG1
UniProt Entry Name
DSS1_HUMAN
NCBI Description
The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008]
Uniprot Description
SHFM1: Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Belongs to the DSS1/SEM1 family.
Protein type: Proteasome complex; Protease; DNA repair, damage
Chromosomal Location of Human Ortholog: 7q21.3
Cellular Component: integrator complex; proteasome complex
Molecular Function: protein binding
Biological Process: double-strand break repair via homologous recombination; proteolysis
Disease: Split-hand/foot Malformation 1
Research Articles on SHFM1
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Product Notes
The SHFM1 shfm1 (Catalog #AAA7005048) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SHFM1 Antibody; HRP conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SHFM1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the SHFM1 shfm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHFM1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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