Western Blot (WB)
(Western blot analysis of lysates from HepG2 cell line,using SHC3_HUMAN(C18734). C18734 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug.)
Rabbit SHC3 HUMAN Polyclonal Antibody | anti-SHC3 antibody
SHC3 HUMAN
Western Blot (WB)
(Western blot analysis of lysates from HepG2 cell line,using SHC3_HUMAN(C18734). C18734 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug.)
Western Blot (WB)
(Western blot analysis of lysates from HepG2 cell line,using SHC3_HUMAN(C18734). C18734 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human lung tissue using SHC3 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human lung tissue using SHC3 antibody.)
Pelicci G.,et al.Oncogene 13:633-641(1996).
Humphray S.J.,et al.Nature 429:369-374(2004).
Liu H.Y.,et al.J. Biol. Chem. 277:26046-26056(2002).
NCBI and Uniprot Product Information
Uniprot Description
SHC3: an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q22.1
Cellular Component: plasma membrane; cytosol
Molecular Function: signal transducer activity; protein binding; receptor tyrosine kinase binding; protein kinase binding
Biological Process: epidermal growth factor receptor signaling pathway; synaptic transmission, glutamatergic; central nervous system development; learning and/or memory; nerve growth factor receptor signaling pathway; Ras protein signal transduction; insulin receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on SHC3
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Product Notes
The SHC3 shc3 (Catalog #AAA9206168) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 305-330. The SHC3 HUMAN reacts with Human, mouse, rat and may cross-react with other species as described in the data sheet. AAA Biotech's SHC3 HUMAN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~ 1:1000. Researchers should empirically determine the suitability of the SHC3 shc3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHC3 HUMAN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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