Rabbit SHC3 Polyclonal Antibody | anti-SHC3 antibody

SHC3 Rabbit Polyclonal

Cat. Num. AAA7604074

• Gene Names: SHC3; RAI; NSHC; SHCC; N-Shc
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SHC3; Polyclonal Antibody; SHC3 Rabbit Polyclonal; anti-SHC3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 594

• Applicable Applications for anti-SHC3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: SHC (Src homology 2 domain containing) transforming protein 3
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas cancer using MBS7604074 (SHC3 antibody) at dilution of 1:50)

Western Blot (WB)

(BxPC-3 cells were subjected to SDS PAGE followed by western blot with MBS7604074 (SHC3 antibody) at dilution of 1:400)

NCBI and Uniprot Product Information

• NCBI GI #: 224586793
• NCBI GeneID: 53358
• NCBI Accession #: NP_058544.3
• NCBI GenBank Nucleotide #: NM_016848.5
• Molecular Weight: 51,939 Da
• NCBI Official Full Name: SHC-transforming protein 3
• NCBI Official Synonym Full Names: SHC adaptor protein 3
• NCBI Official Symbol: SHC3
• NCBI Official Synonym Symbols: RAI; NSHC; SHCC; N-Shc
• NCBI Protein Information: SHC-transforming protein 3
• UniProt Protein Name: SHC-transforming protein 3
• Protein Family: SHC-transforming protein
• UniProt Gene Name: SHC3
• UniProt Synonym Gene Names: NSHC; SHCC; N-Shc; SH2 domain protein C3
• UniProt Entry Name: SHC3_HUMAN

Uniprot Description

SHC3: an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q22.1

Cellular Component: cytosol; plasma membrane

Molecular Function: protein binding; Ras guanyl-nucleotide exchange factor activity; receptor tyrosine kinase binding; signal transducer activity

Biological Process: central nervous system development; epidermal growth factor receptor signaling pathway; learning and/or memory; MAPKKK cascade; positive regulation of GTPase activity; Ras protein signal transduction; synaptic transmission, glutamatergic; transmembrane receptor protein tyrosine kinase signaling pathway