Rabbit SHANK3 Polyclonal Antibody | anti-SHANK3 antibody
SHANK3 Antibody BIOTIN
Gene Names
Shank3; Shank3b; AI841104; SHANK3c-3; SHANK3c-4
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Purity
Immobilized antigen affinity chromatography
Synonyms
SHANK3; Polyclonal Antibody; SHANK3 Antibody BIOTIN; BIOTIN-Conjugated SH3 and multiple ankyrin repeat domains protein 3 Antibody; AI841104 antibody; DEL22q13.3 antibody; KIAA1650 antibody; Proline-rich synapse-associated protein 2 antibody; PSAP2 antibody; SH3 and multiple ankyrin repeat domains 3 antibody; SH3/ankyrin domain gene 3 antibody; SHAN3_HUMAN antibody; Shank postsynaptic density protein antibody; Shank3 antibody; Shank3b antibody; SPANK 2 antibody; anti-SHANK3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immobilized antigen affinity chromatography
Concentration
0.5 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
1730
Applicable Applications for anti-SHANK3 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
ELISA: 1:10,000
IHC: 1:50-1:100
IP: 1:150
WB: 1:500
IHC: 1:50-1:100
IP: 1:150
WB: 1:500
Immunogen
Synthetic peptide taken within amino acid region 1600-1650 on mouse SH3 and multiple ankyrin repeat domains protein 3.
Conjugation
BIOTIN
Molecular Function
GFAP/Homer scaffold activity; identical protein binding; ionotropic glutamate receptor binding; protein C-terminus binding; scaffold protein binding; SH3 domain binding; zinc ion binding
Subcellular Location
Cell junction; Cell Membrane; Cell projection; Cytoplasm; Membrane; Postsynaptic Cell Membrane; Synapse
Preparation and Storage
Store at -20 degree C for long term storage.
Related Product Information for anti-SHANK3 antibody
Overview: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.
Structure: Belongs to the SHANK family. Contains 6 ANK repeats. Contains 1 PDZ (DHR) domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain.
Expression: In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum.
Structure: Belongs to the SHANK family. Contains 6 ANK repeats. Contains 1 PDZ (DHR) domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain.
Expression: In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
88,196 Da
NCBI Official Full Name
SH3 and multiple ankyrin repeat domains protein 3
NCBI Official Synonym Full Names
SH3 and multiple ankyrin repeat domains 3
NCBI Official Symbol
Shank3
NCBI Official Synonym Symbols
Shank3b; AI841104; SHANK3c-3; SHANK3c-4
NCBI Protein Information
SH3 and multiple ankyrin repeat domains protein 3
UniProt Protein Name
SH3 and multiple ankyrin repeat domains protein 3
Protein Family
UniProt Gene Name
Shank3
UniProt Synonym Gene Names
Kiaa1650; Prosap2; Shank3; ProSAP2
Uniprot Description
Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.
Research Articles on SHANK3
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Product Notes
The SHANK3 shank3 (Catalog #AAA5400799) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SHANK3 Antibody BIOTIN reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SHANK3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). ELISA: 1:10,000 IHC: 1:50-1:100 IP: 1:150 WB: 1:500. Researchers should empirically determine the suitability of the SHANK3 shank3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHANK3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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