Mouse anti-Human SH3BP2 Polyclonal Antibody | anti-SH3BP2 antibody

SH3BP2 (SH3 Domain-binding Protein 2, 3BP-2, 3BP2, RES4-23, FLJ42079)

Cat. Num. AAA6012595

• Gene Names: SH3BP2; 3BP2; CRBM; CRPM; 3BP-2; RES4-23
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: SH3BP2; Polyclonal Antibody; SH3BP2 (SH3 Domain-binding Protein 2; 3BP-2; 3BP2; RES4-23; FLJ42079); Anti -SH3BP2 (SH3 Domain-binding Protein 2; anti-SH3BP2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SH3BP2.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MAAEEMHWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLLKWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHISKKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDSSSDTDSFYGAVERPVDISLSPYPTDNEDYEHDDEDDSYLEPDSPEPGRLEDALMHPPAYPPPPVPTPRKPAFSDMPRAHSFTSKGPGPLLPPPPPKHGLPDVGLAAEDSKRDPLCPRRAEPCPRVPATPRRMSDPPLSTMPTAPGLRKPPCFRESASPSPEPWTPGHGACSTSSAAIMATATSRNCDKLKSFHLSPRGPPTSEPPPVPANKPKFLKIAEEDPPREAAMPGLFVPPVAPRPPALKLPVPEAMARPAVLPRPEKPQLPHLQRSPPDGQSFRSFSFEKPRQPSQADTGGDDSDEDYEKVPLPNSVFVNTTESCEVERLFKATSPRGEPQDGLYCIRNSSTKSGKVLVVWDETSNKVRNYRIFEKDSKFYLEGEVLFVSVGSMVEHYHTHVLPSHQSLLLRHPYGYTGPR

• Applicable Applications for anti-SH3BP2 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human SH3BP2, aa1-561 (AAH22996.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of SH3BP2 expression in transfected 293T cell line by SH3BP2 polyclonal antibody.)

Related Product Information for anti-SH3BP2 antibody

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-SH3BP2 antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 224994221
• NCBI GeneID: 6452
• NCBI Accession #: NP_001139328.1
• NCBI GenBank Nucleotide #: NM_001145856.1
• UniProt Accession #: P78314; O00500; O15373; P78315; A6NNC2; B2R5R6; B4DT04; D3DVR0
• Molecular Weight: 62,244 Da
• NCBI Official Full Name: SH3 domain-binding protein 2 isoform b
• NCBI Official Synonym Full Names: SH3-domain binding protein 2
• NCBI Official Symbol: SH3BP2
• NCBI Official Synonym Symbols: 3BP2; CRBM; CRPM; 3BP-2; RES4-23
• NCBI Protein Information: SH3 domain-binding protein 2; Abl-SH3 binding protein 2; TNFAIP3 interacting protein 2
• UniProt Protein Name: SH3 domain-binding protein 2
• Protein Family: SH3 domain-binding protein
• UniProt Gene Name: SH3BP2
• UniProt Synonym Gene Names: 3BP2; 3BP-2
• UniProt Entry Name: 3BP2_HUMAN

NCBI Description

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

SH3BP2: an adaptor protein that binds differentially to the SH3 domains of certain proteins. Links the hemopoietic tyrosine kinase Fes to the cytoplasmic membrane in a phosphorylation dependent manner. Regulates FC-epsilon RI -mediated degranulation in rat basophilic leukemia RBL-2H3 cells. Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. Defects in 3BP2 are the cause of cherubism, an autosomal dominant inherited syndrome. Two differentially spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4p16.3

Molecular Function: protein binding; SH3/SH2 adaptor activity; SH3 domain binding

Biological Process: positive regulation of signal transduction; signal transduction

Disease: Cherubism