Rabbit anti-Human SH2D4A Polyclonal Antibody | anti-SH2D4A antibody

SH2D4A, NT (SH2D4A, SH2A, SH2 domain-containing protein 4A, Protein SH(2)A)

Cat. Num. AAA641893

• Gene Names: SH2D4A; SH2A; PPP1R38
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: SH2D4A; Polyclonal Antibody; NT (SH2D4A; SH2A; SH2 domain-containing protein 4A; Protein SH(2)A); Anti -SH2D4A; anti-SH2D4A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-SH2D4A antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500; Immunohistochemistry: 1:10-50
• Immunogen: SH2D4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-75 amino acids from the N-terminal region of human SH2D4A.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SH2D4A Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SH2D4A antibody detected the SH2D4A protein (arrow).)

Immunohistochemistry (IHC)

(SH2D4A Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SH2D4A Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-SH2D4A antibody

SH2D4A inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.

Product Categories/Family for anti-SH2D4A antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 292658785
• NCBI GeneID: 63898
• NCBI Accession #: NP_001167631.1
• NCBI GenBank Nucleotide #: NM_001174160.1
• UniProt Accession #: Q9H788; Q5XKC1; Q6NXE9; Q86YM2; Q96C88; Q9H7F7; B4DDR1
• Molecular Weight: 52,727 Da
• NCBI Official Full Name: SH2 domain-containing protein 4A isoform b
• NCBI Official Synonym Full Names: SH2 domain containing 4A
• NCBI Official Symbol: SH2D4A
• NCBI Official Synonym Symbols: SH2A; PPP1R38
• NCBI Protein Information: SH2 domain-containing protein 4A; protein SH(2)A; protein phosphatase 1 regulatory subunit 38; protein phosphatase 1, regulatory subunit 38
• UniProt Protein Name: SH2 domain-containing protein 4A
• Protein Family: SH2 domain-containing protein
• UniProt Gene Name: SH2D4A
• UniProt Synonym Gene Names: PPP1R38; SH2A
• UniProt Entry Name: SH24A_HUMAN

Uniprot Description

SH2D4A: Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: cytoplasm

Molecular Function: protein binding; phosphatase binding