Rabbit anti-Mouse SGTA Polyclonal Antibody | anti-SGTA antibody

SGTA (Phospho-Ser301) Antibody

Cat. Num. AAA9429143

• Gene Names: SGTA; SGT; hSGT; alphaSGT
• Reactivity: Mouse
• Applications: Western Blot
• Purity: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
• Synonyms: SGTA; Polyclonal Antibody; SGTA (Phospho-Ser301) Antibody; Alpha SGT; Alpha-SGT; AlphaSGT; hSGT; SGT; Sgt1; SGTA_HUMAN; Small glutamine rich protein with tetratricopeptide repeats 1; Small glutamine rich tetratricopeptide repeat containing protein alpha; Small glutamine rich tetratricopeptide repeat TPR containing alpha; Small glutamine rich tetratricopeptide repeat-containing protein; Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Stg; UBP; Vpu binding protein; Vpu-binding protein;; anti-SGTA antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Phospho-SGTA (Phospho-Ser301) Antibody detects endogenous levels of SGTA only when phosphorylated at Ser301
• Purity/Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0mg/mL (varies by lot)
• Sequence Length: 313

• Applicable Applications for anti-SGTA antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human SGTA around the phosphorylation site of Ser301
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C.

Western Blot (WB)

(Western blot analysis of extracts of Mouse liver tissue sample, using Phospho-SGTA (Ser301) Antibody.(12991))

Product Categories/Family for anti-SGTA antibody

Phospho-specific Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4506921
• NCBI GeneID: 6449
• NCBI Accession #: NP_003012.1
• NCBI GenBank Nucleotide #: NM_003021.3
• UniProt Accession #: O43765; Q6FIA9; Q9BTZ9; D6W610
• Molecular Weight: 34
• NCBI Official Full Name: small glutamine-rich tetratricopeptide repeat-containing protein alpha
• NCBI Official Synonym Full Names: small glutamine rich tetratricopeptide repeat containing alpha
• NCBI Official Symbol: SGTA
• NCBI Official Synonym Symbols: SGT; hSGT; alphaSGT
• NCBI Protein Information: small glutamine-rich tetratricopeptide repeat-containing protein alpha
• UniProt Protein Name: Small glutamine-rich tetratricopeptide repeat-containing protein alpha
• Protein Family: Small glutamine-rich tetratricopeptide repeat-containing protein
• UniProt Gene Name: SGTA
• UniProt Synonym Gene Names: SGT; SGT1; UBP

NCBI Description

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

Uniprot Description

Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).