Rabbit anti-Human SGSH Polyclonal Antibody | anti-SGSH antibody

SGSH (HSS, N-sulphoglucosamine Sulphohydrolase, Sulfoglucosamine Sulfamidase, Sulphamidase) (Biotin)

Cat. Num. AAA6394038

• Gene Names: SGSH; HSS; SFMD; MPS3A
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SGSH; Polyclonal Antibody; SGSH (HSS; N-sulphoglucosamine Sulphohydrolase; Sulfoglucosamine Sulfamidase; Sulphamidase) (Biotin); anti-SGSH antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SGSH.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-SGSH antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human SGSH, aa1-502 (NP_000190.1).
• Immunogen Sequence: MSCPVPACCALLLVLGLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNEL
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SGSH rabbit polyclonal antibody. Western Blot analysis of SGSH expression in human liver.)

Western Blot (WB)

(Western Blot analysis of SGSH expression in transfected 293T cell line by SGSH polyclonal antibody. Lane 1: SGSH transfected lysate (56.7kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-SGSH antibody

SGSH is one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined.

Product Categories/Family for anti-SGSH antibody

Antibodies; Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 4506919
• NCBI GeneID: 6448
• NCBI Accession #: NP_000190.1
• NCBI GenBank Nucleotide #: NM_000199.2
• UniProt Accession #: P51688; A8K5E2
• Molecular Weight: 56,695 Da
• NCBI Official Full Name: N-sulphoglucosamine sulphohydrolase
• NCBI Official Synonym Full Names: N-sulfoglucosamine sulfohydrolase
• NCBI Official Symbol: SGSH
• NCBI Official Synonym Symbols: HSS; SFMD; MPS3A
• NCBI Protein Information: N-sulphoglucosamine sulphohydrolase
• UniProt Protein Name: N-sulphoglucosamine sulphohydrolase
• Protein Family: N-sulphoglucosamine sulphohydrolase
• UniProt Gene Name: SGSH
• UniProt Synonym Gene Names: HSS
• UniProt Entry Name: SPHM_HUMAN

NCBI Description

This gene encodes one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined. [provided by RefSeq, Jul 2008]