Rabbit anti-Human, Mouse SGK1 Polyclonal Antibody | anti-SGK1 antibody

SGK1 Rabbit Polyclonal

Cat. Num. AAA7604039

• Gene Names: SGK1; SGK
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SGK1; Polyclonal Antibody; SGK1 Rabbit Polyclonal; anti-SGK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 445

• Applicable Applications for anti-SGK1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
• Immunogen: Serum/glucocorticoid regulated kinase 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human esophagus using MBS7604039 (SGK1 Antibody) at dilution of 1:50)

Western Blot (WB)

(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7604039 (SGK1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 219521880
• NCBI GeneID: 6446
• NCBI Accession #: NP_001137150.1
• NCBI GenBank Nucleotide #: NM_001143678.1
• Molecular Weight: 52,119 Da
• NCBI Official Full Name: serine/threonine-protein kinase Sgk1 isoform 4
• NCBI Official Synonym Full Names: serum/glucocorticoid regulated kinase 1
• NCBI Official Symbol: SGK1
• NCBI Official Synonym Symbols: SGK
• NCBI Protein Information: serine/threonine-protein kinase Sgk1
• UniProt Protein Name: Serine/threonine-protein kinase Sgk1
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: SGK1
• UniProt Synonym Gene Names: SGK
• UniProt Entry Name: SGK1_HUMAN

NCBI Description

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Uniprot Description

SGK1: serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation.

Protein type: Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; Kinase, protein; AGC group; SGK family

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: 3-phosphoinositide-dependent protein kinase binding; ATP binding; calcium channel regulator activity; chloride channel regulator activity; cofactor binding; potassium channel regulator activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; sodium channel regulator activity; tau protein binding

Biological Process: apoptosis; cellular sodium ion homeostasis; glucocorticoid mediated signaling; long-term memory; microtubule depolymerization; negative regulation of apoptosis; negative regulation of microtubule polymerization; neurite morphogenesis; peptidyl-serine phosphorylation; positive regulation of cell growth; positive regulation of dendrite morphogenesis; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of blood pressure; regulation of catalytic activity; regulation of cell cycle; regulation of cell growth; regulation of cell migration; regulation of cell proliferation; regulation of transcription factor activity; response to DNA damage stimulus; response to stress; sodium ion transport; visual learning