Rabbit anti-Human SFRS11 Polyclonal Antibody | anti-SFRS11 antibody

SFRS11, CT (SRSF11, SFRS11, Serine/arginine-rich splicing factor 11, Arginine-rich 54kD nuclear protein, Splicing factor, arginine/serine-rich 11) (PE)

Cat. Num. AAA6346646

• Gene Names: SRSF11; p54; NET2; SFRS11; dJ677H15.2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SFRS11; Polyclonal Antibody; CT (SRSF11; Serine/arginine-rich splicing factor 11; Arginine-rich 54kD nuclear protein; Splicing factor; arginine/serine-rich 11) (PE); SRSF11; arginine/serine-rich 11; anti-SFRS11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-SFRS11 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SFRS11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-395 amino acids from the C-terminal region of human SFRS11.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SFRS11 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SFRS11 antibody detected the SFRS11 protein (arrow).)

Related Product Information for anti-SFRS11 antibody

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.

Product Categories/Family for anti-SFRS11 antibody

Antibodies; Splicing Factors

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Manley, J.L., et al. Genes Dev. 24(11):1073-1074(2010). Casado, P., et al. J Proteomics 71(6):592-600(2009). Shepard, P.J., et al. Genome Biol. 10 (10), 242 (2009): Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 4759100
• NCBI GeneID: 9295
• NCBI Accession #: NP_004759.1
• NCBI GenBank Nucleotide #: NM_001190987
• UniProt Accession #: Q05519
• Molecular Weight: 45
• NCBI Official Full Name: serine/arginine-rich splicing factor 11 isoform 1
• NCBI Official Synonym Full Names: serine and arginine rich splicing factor 11
• NCBI Official Symbol: SRSF11
• NCBI Official Synonym Symbols: p54; NET2; SFRS11; dJ677H15.2
• NCBI Protein Information: serine/arginine-rich splicing factor 11
• UniProt Protein Name: Serine/arginine-rich splicing factor 11
• UniProt Gene Name: SRSF11
• UniProt Synonym Gene Names: SFRS11; p54
• UniProt Entry Name: SRS11_HUMAN

NCBI Description

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]

Uniprot Description

SRSF11: May function in pre-mRNA splicing. Belongs to the splicing factor SR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing; RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; nucleotide binding

Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription