Western Blot (WB)
(Western blot analysis of extracts of various cells, using 213333.)
Rabbit SFPQ Polyclonal Antibody | anti-SFPQ antibody
SFPQ (Splicing Factor Proline and Glutamine Rich, POMP100, PSF) (APC)
Gene Names
SFPQ; PSF; POMP100; PPP1R140
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Purified by affinity chromatography.
Synonyms
SFPQ; Polyclonal Antibody; SFPQ (Splicing Factor Proline and Glutamine Rich; POMP100; PSF) (APC); anti-SFPQ antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human SFPQ. Species Crossreactivity: mouse and rat
Purity/Purification
Purified by affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Applicable Applications for anti-SFPQ antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
Recombinant protein corresponding to human SFPQ.
Conjugate
APC
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(Western blot analysis of extracts of various cells, using 213333.)
Western Blot (WB)
(Western blot analysis of extracts of various cells, using 213333.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human Muscle using 213333.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human Muscle using 213333.)
Related Product Information for anti-SFPQ antibody
SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47kD, 52kD or 100kD molecules in various cell types.
Product Categories/Family for anti-SFPQ antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
Calculated MW: 72kDa/76kDa
Observed MW: 115kDa
Observed MW: 115kDa
NCBI Official Full Name
Splicing factor, proline- and glutamine-rich
NCBI Official Synonym Full Names
splicing factor proline/glutamine-rich
NCBI Official Symbol
SFPQ
NCBI Official Synonym Symbols
PSF; POMP100; PPP1R140
NCBI Protein Information
splicing factor, proline- and glutamine-rich; hPOMp100; 100 kDa DNA-pairing protein; PTB-associated splicing factor; PTB-associated-splicing factor; DNA-binding p52/p100 complex, 100 kDa subunit; protein phosphatase 1, regulatory subunit 140; polypyrimidi
UniProt Protein Name
Splicing factor, proline- and glutamine-rich
Protein Family
UniProt Gene Name
SFPQ
UniProt Synonym Gene Names
PSF; hPOMp100; PSF; PTB-associated-splicing factor
UniProt Entry Name
SFPQ_HUMAN
Uniprot Description
PSF: a proline-and glutamine-rich splicing factor. Essential pre-mRNA splicing factor required early in spliceosome formation. Seems to also bind DNA. The active complex is a heterotetramer of two 52 kDa and two 100 kDa subunits. Reported to be a PKC-alpha-binding protein in the cell nucleus. Two alternatively spliced isoforms have been described.
Protein type: RNA splicing; RNA-binding; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component: nucleoplasm; nuclear matrix; cytoplasm; nucleus; paraspeckles; chromatin
Molecular Function: protein binding; histone deacetylase binding; nucleotide binding
Biological Process: alternative nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; RNA splicing; rhythmic process; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; DNA repair; mRNA processing; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; DNA recombination
Research Articles on SFPQ
Similar Products
Product Notes
The SFPQ sfpq (Catalog #AAA6437321) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SFPQ (Splicing Factor Proline and Glutamine Rich, POMP100, PSF) (APC) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SFPQ can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SFPQ sfpq for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SFPQ, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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