Rabbit anti-Human Sestrin 1 Polyclonal Antibody | anti-SEST1 antibody

Sestrin 1 (Sestrin-1, SESN1, SEST1, p53-regulated Protein PA26, PA26) (HRP)

Cat. Num. AAA6393864

• Gene Names: SESN1; PA26; SEST1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Sestrin 1; Polyclonal Antibody; Sestrin 1 (Sestrin-1; SESN1; SEST1; p53-regulated Protein PA26; PA26) (HRP); anti-SEST1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SESN1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Sequence Length: 5664

• Applicable Applications for anti-SEST1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human SESN1, aa1-551 (NP_055269.1).
• Immunogen Sequence: MAEGENEVRWDGLCSRDSTTRETALENIRQTILRKTEYLRSVKETPHRPSDGLSNTESSDGLNKLLAHLLMLSKRCPFKDVREKSEFILKSIQELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of SESN1 expression in transfected 293T cell line by SESN1 polyclonal antibody. Lane 1: SESN1 transfected lysate (63.8kD). Lane 2: Non-transfected lysate. )

Product Categories/Family for anti-SEST1 antibody

Antibodies; Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 1701108466
• NCBI GeneID: 27244
• NCBI Accession #: NM_014454.3
• NCBI GenBank Nucleotide #: NM_014454
• NCBI Official Full Name: Homo sapiens sestrin 1 (SESN1), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: sestrin 1
• NCBI Official Symbol: SESN1
• NCBI Official Synonym Symbols: PA26; SEST1
• NCBI Protein Information: sestrin-1

NCBI Description

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]