Rabbit anti-Human SERPINI2 Polyclonal Antibody | anti-SERPINI2 antibody

SERPINI2, CT (SERPINI2, MEPI, PI14, Serpin I2, Myoepithelium-derived serine protease inhibitor, Pancpin, Pancreas-specific protein TSA2004, Peptidase inhibitor 14) (PE)

Cat. Num. AAA6346393

• Gene Names: SERPINI2; MEPI; PI14; PANCPIN; TSA2004
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SERPINI2; Polyclonal Antibody; CT (SERPINI2; MEPI; PI14; Serpin I2; Myoepithelium-derived serine protease inhibitor; Pancpin; Pancreas-specific protein TSA2004; Peptidase inhibitor 14) (PE); Peptidase inhibitor 14; anti-SERPINI2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-SERPINI2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SERPINI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-401 amino acids from the C-terminal region of human SERPINI2.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SERPINI2 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the SERPINI2 antibody detected the SERPINI2 protein (arrow).)

Related Product Information for anti-SERPINI2 antibody

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.

Product Categories/Family for anti-SERPINI2 antibody

Antibodies; Protease Inhibitors

References

Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010). Lim, J., et al. Cell 125(4):801-814(2006). Chang, W.S., et al. Genes Chromosomes Cancer 29(3):240-255(2000). Xiao, G., et al. Proc. Natl. Acad. Sci. U.S.A. 96(7):3700-3705(1999). Ozaki, K., et al. Genes Chromosomes Cancer 22(3):179-185(1998).

NCBI and Uniprot Product Information

• NCBI GI #: 5453886
• NCBI GeneID: 5276
• NCBI Accession #: NP_006208.1; NP_001012303.1
• NCBI GenBank Nucleotide #: NM_006217.4
• UniProt Accession #: O75830
• Molecular Weight: 46,145 Da
• NCBI Official Full Name: serpin I2 isoform 2
• NCBI Official Synonym Full Names: serpin family I member 2
• NCBI Official Symbol: SERPINI2
• NCBI Official Synonym Symbols: MEPI; PI14; PANCPIN; TSA2004
• NCBI Protein Information: serpin I2
• UniProt Protein Name: Serpin I2
• Protein Family: Serpin
• UniProt Gene Name: SERPINI2
• UniProt Synonym Gene Names: MEPI; PI14; PI-14
• UniProt Entry Name: SPI2_HUMAN

NCBI Description

The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Uniprot Description

Subcellular location: Secreted

Probable.

Tissue specificity: Expressed in pancreas and adipose tissues. Ref.1

Sequence similarities: Belongs to the serpin family.

Sequence caution: The sequence AAH27859.2 differs from that shown. Reason: Erroneous initiation.