Western Blot (WB)
(Anti- SerpinB2 Picoband antibody, MBS177850, Western blottingAll lanes: Anti SerpinB2 (MBS177850) at 0.5ug/mlWB: Human Placenta Tissue Lysate at 50ugPredicted bind size: 47KDObserved bind size: 47KD)
anti-Human SerpinB2 Polyclonal Antibody | anti-SERPINB2 antibody
Anti-SerpinB2 Antibody
Gene Names
SERPINB2; PAI; PAI2; PAI-2; PLANH2; HsT1201
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Immunogen Affinity Purified
Synonyms
SerpinB2; Polyclonal Antibody; Anti-SerpinB2 Antibody; Plasminogen activator inhibitor 2; HsT1201; Monocyte Arg serpin; Monocyte Arg-serpin; Monocyte Arginine-serpin; Monocyte-derived plasminogen activator inhibitor; PAI; PAI-2; PAI2; PAI2_HUMAN; Placental plasminogen activator inhibitor; PLANH2; plasminogen activator inhibitor; type 2; type II (arginine-serpin); serine (or cysteine) proteinase inhibitor; clade B (ovalbumin); member 2; Serpin B2; serpin peptidase inhibitor; Serpinb2; Urokinase inhibitor; anti-SERPINB2 antibody
Reactivity
Human
Clonality
Polyclonal
Purity/Purification
Immunogen Affinity Purified
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
415
Applicable Applications for anti-SERPINB2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Immunogen
E Coli-derived human SerpinB2 recombinant protein (Position: M1-K180). Human SerpinB2 shares 70% and 66% amino acid (aa) sequence identity with mouse and rat SerpinB2, respectively.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Western Blot (WB)
(Anti- SerpinB2 Picoband antibody, MBS177850, Western blottingAll lanes: Anti SerpinB2 (MBS177850) at 0.5ug/mlWB: Human Placenta Tissue Lysate at 50ugPredicted bind size: 47KDObserved bind size: 47KD)
Western Blot (WB)
(Anti- SerpinB2 Picoband antibody, MBS177850, Western blottingAll lanes: Anti SerpinB2 (MBS177850) at 0.5ug/mlWB: Human Placenta Tissue Lysate at 50ugPredicted bind size: 47KDObserved bind size: 47KD)
Immunohistochemistry (IHC)
(Anti- SerpinB2 Picoband antibody, MBS177850,IHC(P)IHC(P): Human Placenta Tissue )
Immunohistochemistry (IHC)
(Anti- SerpinB2 Picoband antibody, MBS177850,IHC(P)IHC(P): Human Placenta Tissue )
Related Product Information for anti-SERPINB2 antibody
Description: Rabbit IgG polyclonal antibody for Plasminogen activator inhibitor 2(SERPINB2) detection. Tested with WB, IHC-P in Human.
Background: SERPINB2 is also known as PAI or PAI2. Plasminogen activator inhibitor-2 (placental PAI) is acoagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form. It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosisduring pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.
Background: SERPINB2 is also known as PAI or PAI2. Plasminogen activator inhibitor-2 (placental PAI) is acoagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60-kDa extracellular glycosylated form and a 43-kDa intracellular form. It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosisduring pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.
References
1. Corsetti JP, et al. Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels. PLoS One, 2013. 2. Huang Z, et al. SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer. Mol Carcinog, 2014 Oct. 3. Jin Y, et al. Expression of plasminogen activator inhibitor-2 is negatively associated with invasive potential in hepatocellular carcinoma cells. Chin Med Sci J, 2013 Mar. 4. Zhou L, et al. Low expression of PAI-2 as a novel marker of portal vein tumor thrombosis and poor prognosis in hepatocellular carcinoma. World J Surg, 2013 Mar.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46,596 Da
NCBI Official Full Name
plasminogen activator inhibitor 2
NCBI Official Synonym Full Names
serpin family B member 2
NCBI Official Symbol
SERPINB2
NCBI Official Synonym Symbols
PAI; PAI2; PAI-2; PLANH2; HsT1201
NCBI Protein Information
plasminogen activator inhibitor 2
UniProt Protein Name
Plasminogen activator inhibitor 2
Protein Family
UniProt Gene Name
SERPINB2
UniProt Synonym Gene Names
PAI2; PLANH2; PAI-2
UniProt Entry Name
PAI2_HUMAN
Uniprot Description
SERPINB2: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1. Belongs to the serpin family. Ov-serpin subfamily.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 18q21.3
Cellular Component: cytoplasm; extracellular region; extracellular space; plasma membrane
Molecular Function: serine-type endopeptidase inhibitor activity
Biological Process: fibrinolysis; negative regulation of apoptosis; wound healing
Research Articles on SERPINB2
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Product Notes
The SERPINB2 serpinb2 (Catalog #AAA177850) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-SerpinB2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SerpinB2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot Concentration: 0.1-0.5ug/ml Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the SERPINB2 serpinb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SerpinB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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