Rabbit anti-Human SERPINA5 Polyclonal Antibody | anti-SERPINA5 antibody

SERPINA5, NT (SERPINA5, PCI, PLANH3, PROCI, Plasma serine protease inhibitor, Acrosomal serine protease inhibitor, Plasminogen activator inhibitor 3, Protein C inhibitor, Serpin A5) (MaxLight 550)

Cat. Num. AAA6346269

• Gene Names: SERPINA5; PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SERPINA5; Polyclonal Antibody; NT (SERPINA5; PCI; PLANH3; PROCI; Plasma serine protease inhibitor; Acrosomal serine protease inhibitor; Plasminogen activator inhibitor 3; Protein C inhibitor; Serpin A5) (MaxLight 550); Serpin A5; anti-SERPINA5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-SERPINA5 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SERPINA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the N-terminal region of human SERPINA5.
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-SERPINA5 antibody

SERPINA5 inhibits activated protein C as well as plasminogen activators.

Product Categories/Family for anti-SERPINA5 antibody

Antibodies; Protease Inhibitors

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Blomstrand, D., et al. Ann Vasc Surg 24(5):588-595(2010). Bungum, M., et al. Fertil. Steril. 93(1):277-279(2010). Malmstrom, E., et al. PLoS Pathog. 5 (12), E1000698 (2009): Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 194018472
• NCBI GeneID: 5104
• NCBI Accession #: NP_000615.3
• NCBI GenBank Nucleotide #: NM_000624.5
• UniProt Accession #: P05154; Q07616; Q9UG30
• Molecular Weight: 45,675 Da
• NCBI Official Full Name: plasma serine protease inhibitor preproprotein
• NCBI Official Synonym Full Names: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
• NCBI Official Symbol: SERPINA5
• NCBI Official Synonym Symbols: PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3
• NCBI Protein Information: plasma serine protease inhibitor; serpin A5; protein C inhibitor; plasminogen activator inhibitor-3; acrosomal serine protease inhibitor; plasminogen activator inhibitor III; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, anti
• UniProt Protein Name: Plasma serine protease inhibitor
• Protein Family: Plasma serine protease inhibitor
• UniProt Gene Name: SERPINA5
• UniProt Synonym Gene Names: PCI; PLANH3; PROCI; PAI-3; PAI3; PCI
• UniProt Entry Name: IPSP_HUMAN

NCBI Description

The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]

Uniprot Description

SERPINA5: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary- type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as an hydrophobic hormone carrier by its binding to retinoic acid. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space; protein complex; membrane; extracellular region; acrosomal membrane; external side of plasma membrane

Molecular Function: acrosin binding; heparin binding; serine-type endopeptidase inhibitor activity; glycosaminoglycan binding; retinoic acid binding; protease binding; phosphatidylcholine binding

Biological Process: fusion of sperm to egg plasma membrane; spermatogenesis; lipid transport; blood coagulation