Rabbit anti-Human Serotonin Transporter (SERT) Polyclonal Antibody | anti-SERT antibody
HRP-Linked Polyclonal Antibody to Serotonin Transporter (SERT)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
Uniprot Description
SERT: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cytosol; endomembrane system; integral to plasma membrane; lipid raft; neuron projection; plasma membrane
Molecular Function: actin filament binding; monoamine transmembrane transporter activity; protein binding; Rab GTPase binding; serotonin transmembrane transporter activity; serotonin:sodium symporter activity
Biological Process: brain morphogenesis; monoamine transport; negative regulation of organ growth; protein oligomerization; response to toxin; serotonin transport; serotonin uptake; social behavior; synaptic transmission; thalamus development
Disease: Anxiety; Obsessive-compulsive Disorder